Anti-Müllerian hormone does not predict time to pregnancy: results of a prospective cohort study

M. Depmann, S. L. Broer, M. J.C. Eijkemans, I. A.J. van Rooij, G. J. Scheffer, J. Heimensem, B. W. Mol, F. J.M. Broekmans

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Abstract

In order to study whether ovarian reserve tests (ORTs) can predict time to ongoing pregnancy, we conducted a prospective cohort study in a cohort of healthy pregnancy planners. A total of 102 pregnancy planners were followed for 1 year, or until ongoing pregnancy occurred, after cessation of contraceptives). A baseline measurement of anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH) and antral follicle count (AFC) was conducted. At the end of follow-up, a semen analysis was performed and chlamydia antibody titres were assessed. A univariate prediction model demonstrated age and the AFC to be significantly capable of predicting time to pregnancy (hazard ratio 0.92, 95% CI 0.87–0.98, p = 0.01; 1.04, 95% CI 1.01–1.07, p = 0.02 respectively). In the multivariate model, however, correcting for female age, we found no predictive effect of AMH, basal FSH or the AFC for time to ongoing pregnancy (hazard ratios 1.43, 95% CI 0.84–2.46, p = 0.36; 0.96, 95% CI 0.86–1.06, p = 0.43; 1.03, 95% CI 1.00–1.07, p = 0.08, respectively). This was confirmed by the low C-statistic. We therefore concluded that baseline AMH, AFC or FSH levels do not predict time to ongoing pregnancy in a cohort of healthy pregnancy planners. These results limit the usability of these ORTs in the assessment of current fertility.

Original languageEnglish
Pages (from-to)644-648
Number of pages5
JournalGynecological Endocrinology
Volume33
Issue number8
DOIs
Publication statusPublished - 3 Aug 2017
Externally publishedYes

Keywords

  • AMH
  • conception
  • fecundability
  • prediction
  • pregnancy

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