Anti-inflammatory therapy in an ovine model of fetal hypoxia induced by single umbilical artery ligation

Micka C Bertucci; Jan Mi Loose; Euan M Wallace; Graham Jenkin; Suzanne L Miller

doi:10.1071/RD10110

Anti-inflammatory therapy in an ovine model of fetal hypoxia induced by single umbilical artery ligation

Micka C Bertucci, Jan Mi Loose, Euan M Wallace, Graham Jenkin, Suzanne L Miller

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18 Citations (Scopus)

Abstract

Perinatal morbidity and mortality are significantly higher in pregnancies complicated by chronic hypoxia and intrauterine growth restriction (IUGR). Clinically, placental insufficiency and IUGR are strongly associated with a fetoplacental inflammatory response. To explore this further, hypoxia was induced in one fetus in twin-bearing pregnant sheep (n=9) by performing single umbilical artery ligation (SUAL) at 110 days gestation. Five ewes were administered the anti-inflammatory drug sulfasalazine (SSZ) daily, beginning 24h before surgery. Fetal blood gases and inflammatory markers were examined. In both SSZ- and placebo-treated ewes, SUAL fetuses were hypoxic and growth-restricted at 1 week (P

Original language	English
Pages (from-to)	346 - 352
Number of pages	7
Journal	Reproduction, Fertility and Development
Volume	23
Issue number	2
DOIs	https://doi.org/10.1071/RD10110
Publication status	Published - 2011

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abstract = "Perinatal morbidity and mortality are significantly higher in pregnancies complicated by chronic hypoxia and intrauterine growth restriction (IUGR). Clinically, placental insufficiency and IUGR are strongly associated with a fetoplacental inflammatory response. To explore this further, hypoxia was induced in one fetus in twin-bearing pregnant sheep (n=9) by performing single umbilical artery ligation (SUAL) at 110 days gestation. Five ewes were administered the anti-inflammatory drug sulfasalazine (SSZ) daily, beginning 24h before surgery. Fetal blood gases and inflammatory markers were examined. In both SSZ- and placebo-treated ewes, SUAL fetuses were hypoxic and growth-restricted at 1 week (P",

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AU - Loose, Jan Mi

AU - Wallace, Euan M

AU - Jenkin, Graham

AU - Miller, Suzanne L

PY - 2011

Y1 - 2011

N2 - Perinatal morbidity and mortality are significantly higher in pregnancies complicated by chronic hypoxia and intrauterine growth restriction (IUGR). Clinically, placental insufficiency and IUGR are strongly associated with a fetoplacental inflammatory response. To explore this further, hypoxia was induced in one fetus in twin-bearing pregnant sheep (n=9) by performing single umbilical artery ligation (SUAL) at 110 days gestation. Five ewes were administered the anti-inflammatory drug sulfasalazine (SSZ) daily, beginning 24h before surgery. Fetal blood gases and inflammatory markers were examined. In both SSZ- and placebo-treated ewes, SUAL fetuses were hypoxic and growth-restricted at 1 week (P

AB - Perinatal morbidity and mortality are significantly higher in pregnancies complicated by chronic hypoxia and intrauterine growth restriction (IUGR). Clinically, placental insufficiency and IUGR are strongly associated with a fetoplacental inflammatory response. To explore this further, hypoxia was induced in one fetus in twin-bearing pregnant sheep (n=9) by performing single umbilical artery ligation (SUAL) at 110 days gestation. Five ewes were administered the anti-inflammatory drug sulfasalazine (SSZ) daily, beginning 24h before surgery. Fetal blood gases and inflammatory markers were examined. In both SSZ- and placebo-treated ewes, SUAL fetuses were hypoxic and growth-restricted at 1 week (P

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JO - Reproduction, Fertility and Development

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IS - 2

ER -

Anti-inflammatory therapy in an ovine model of fetal hypoxia induced by single umbilical artery ligation

Abstract

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