Anti-inflammatory therapy in an ovine model of fetal hypoxia induced by single umbilical artery ligation

Micka C Bertucci, Jan Mi Loose, Euan M Wallace, Graham Jenkin, Suzanne L Miller

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12 Citations (Scopus)

Abstract

Perinatal morbidity and mortality are significantly higher in pregnancies complicated by chronic hypoxia and intrauterine growth restriction (IUGR). Clinically, placental insufficiency and IUGR are strongly associated with a fetoplacental inflammatory response. To explore this further, hypoxia was induced in one fetus in twin-bearing pregnant sheep (n=9) by performing single umbilical artery ligation (SUAL) at 110 days gestation. Five ewes were administered the anti-inflammatory drug sulfasalazine (SSZ) daily, beginning 24h before surgery. Fetal blood gases and inflammatory markers were examined. In both SSZ- and placebo-treated ewes, SUAL fetuses were hypoxic and growth-restricted at 1 week (P
Original languageEnglish
Pages (from-to)346 - 352
Number of pages7
JournalReproduction, Fertility and Development
Volume23
Issue number2
DOIs
Publication statusPublished - 2011

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