Anti-inflammatory activity and mechanisms of a lipid extract from hard-shelled mussel (Mytilus coruscus) in mice with dextran sulphate sodium-induced colitis

Fenglei Wang, Yuanqing Fu, Wenwen Cai, Andrew J. Sinclair, Duo Li

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12 Citations (Scopus)

Abstract

The anti-inflammatory effect of a lipid extract from hard-shelled mussel (HMLE) on dextran sulphate sodium (DSS)-induced colitis in mice was investigated. Salicylazosulphapyridine (SASP) and different doses of HMLE were administered by gastric gavage. HMLE significantly attenuated DSS-induced colitis disease activity index scores, tissue damage, splenic enlargement and colon myeloperoxidase accumulation. In addition, HMLE improved colon oxidative stress and production and expression of anti-inflammatory cytokine, interleukin (IL)-10, while HMLE inhibited the abnormal productions and mRNA expressions of pro-inflammatory cytokines, namely tumour necrosis factor-α, IL-1β, and IL-6, as well as the expression of key molecules in the toll-like receptor (TLR)-4/nuclear factor (NF)-κB signalling pathway. These findings suggest that HMLE has an anti-inflammatory effect on DSS-induced colitis, equivalent to that of SASP, and this effect might be related to the regulation of inflammatory mediators and key molecules in the TLR-4/NF-κB pathway.

Original languageEnglish
Pages (from-to)389-399
Number of pages11
JournalJournal of Functional Foods
Volume23
DOIs
Publication statusPublished - 1 May 2016
Externally publishedYes

Keywords

  • Anti-inflammatory
  • Colitis
  • Hard-shelled mussel
  • Lipid extract
  • Salicylazosulphapyridine
  • TLR-4/NF-κB pathway

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