Anti-HIV activity of Indian medicinal plants

Sudeep Sabde, Hardik S. Bodiwala, Aniket Karmase, Preeti J. Deshpande, Amandeep Kaur, Nafees Ahmed, Siddheshwar K. Chauthe, Keyur G. Brahmbhatt, Rasika U. Phadke, Debashis Mitra, Kamlesh Kumar Bhutani, Inder Pal Singh

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41 Citations (Scopus)

Abstract

Acquired immunodeficiency syndrome patients face great socio-economic difficulties in obtaining treatment. There is an urgent need for new, safe, and cheap anti-HIV agents. Traditional medicinal plants are a valuable source of novel anti-HIV agents and may offer alternatives to expensive medicines in future. Various medicinal plants or plant-derived natural products have shown strong anti-HIV activity and are under various stages of clinical development in different parts of the world. The present study was directed towards assessment of anti-HIV activity of various extracts prepared from Indian medicinal plants. The plants were chosen on the basis of similarity of chemical constituents with reported anti-HIV compounds or on the basis of their traditional usage as immunomodulators. Different extracts were prepared by Soxhlet extraction and liquid-liquid partitioning. Ninety-two extracts were prepared from 23 plants. Anti-HIV activity was measured in a human CD4+ T-cell line, CEM-GFP cells infected with HIV-1NL4.3. Nine extracts of 8 different plants significantly reduced viral production in CEM-GFP cells infected with HIV-1NL4.3. Aegle marmelos, Argemone mexicana, Asparagus racemosus, Coleus forskohlii, and Rubia cordifolia demonstrated promising anti-HIV potential and were investigated for their active principles.

Original languageEnglish
Pages (from-to)662-669
Number of pages8
JournalJournal of Natural Medicines
Volume65
Issue number3-4
DOIs
Publication statusPublished - Jul 2011
Externally publishedYes

Keywords

  • AIDS
  • Anti-HIV
  • Medicinal plants
  • Plant extracts
  • Reverse transcriptase inhibitor

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