Anti-HIV-1 antibody-dependent cellular cytotoxicity: Is there more to antibodies than neutralization?

Wen Shi Lee, Stephen J. Kent

Research output: Contribution to journalReview ArticleOtherpeer-review

19 Citations (Scopus)

Abstract

Purpose of review An increasing body of evidence suggests that nonneutralizing Fc effector functions including antibody-dependent cellular cytotoxicity (ADCC) contribute to protection against HIV-1 acquisition. We discuss recent advances in anti-HIV-1 ADCC research with a particular focus on ADCC mediated by Env-specific antibodies in vitro and in vivo, the curative potential of HIV-1-specific ADCC antibodies and the mechanisms of HIV-1 resistance to ADCC. Recent findings ADCC activities of broadly neutralizing and nonneutralizing monoclonal antibody panels were recently characterized in vitro against several lab-adapted and primary isolates of HIV-1. ADCC activity of these monoclonal antibodies generally correlated with binding to infected cells and were greater against the lab-adapted strains compared with primary HIV-1 isolates. Several recent studies in mouse and macaque models of HIV-1 infection suggest Fc-mediated effector functions contribute to the protective efficacy of broadly neutralizing antibodies and exert immune pressure on HIV-1 in vivo. Summary An increasing body of evidence suggests that ADCC-mediating antibodies, particularly when combined with neutralizing functions, can facilitate prevention and control of HIV-1. The precise mechanisms of partial protection conferred by nonneutralizing antibodies in vivo remain unclear and will need to be fully investigated in order to realize their full potential for HIV-1 vaccines.

Original languageEnglish
Pages (from-to)160-166
Number of pages7
JournalCurrent Opinion in HIV and AIDS
Volume13
Issue number2
DOIs
Publication statusPublished - 1 Mar 2018

Keywords

  • antibody-dependent cellular cytotoxicity
  • broadly neutralizing antibody
  • Fc-mediated effector functions
  • nonneutralizing

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