Abstract
There are a number of therapeutic targets to treat organ fibrosis that are under investigation in preclinical models. There is increasing evidence that stimulation of the angiotensin II type 2 receptor (AT2 R) is a novel anti-fibrotic strategy and we have reviewed the published in vivo preclinical data relating to the effects of compound 21 (C21), which is the only nonpeptide AT2 R agonist that is currently available for use in chronic preclinical studies. In particular, the differential influence of AT2 R on extracellular matrix status in various preclinical fibrotic models is discussed. Collectively, these studies demonstrate that pharmacological AT2 R stimulation using C21 decreases organ fibrosis, which has been most studied in the setting of cardiovascular and renal disease. In addition, AT2 R-mediated anti-inflammatory effects may contribute to the beneficial AT2 R-mediated anti-fibrotic effects seen in preclinical models.
Original language | English |
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Article number | 564 |
Number of pages | 7 |
Journal | Frontiers in Pharmacology |
Volume | 8 |
DOIs | |
Publication status | Published - 31 Aug 2017 |
Keywords
- AT receptor
- Cardiac fibrosis
- Compound 21
- Inflammation
- Renal fibrosis