Anti-aquaporin-4 antibody positivity in neuromyelitis optica is associated with lesion activity

Yaou Liu, Yue Han, Yunyun Duan, Jing Huang, Zhuoqiong Ren, Helmut Butzkueven, Kuncheng Li

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Aims: To assess the demographic, clinical and spinal cord MRI characteristics of clinically definite neuromyelitis optica (NMO) patients for association with anti-aquaporin-4 (AQP4) antibody positivity in Chinese patients. Methods: We recruited 72 consecutive patients with NMO. The clinical assessments, sera and spinal MRI scans were obtained within 1 week after the onset of symptoms of acute myelitis. The statistical significance of potential differences in demographic, clinical and spinal MRI lesion characteristics between the two groups (anti-AQP4 antibody positive vs. negative) was determined using the two-sample t test or Fisher's exact test. Results: Forty-nine patients (49/72, 68.1%) were anti-AQP4 antibody positive and 23 patients (23/72, 31.9%) were anti-AQP4 antibody negative. The only characteristic that was significantly different between the groups was the presence of an enhancing spinal cord lesion (p < 0.001). Conclusion: We found a strong association between serum anti-AQP4 antibody positivity and lesional gadolinium enhancement in patients with clinically definite NMO. These findings support prior evidence that anti-AQP4 antibody could be pathogenic in NMO lesion development.

Original languageEnglish
Pages (from-to)113-116
Number of pages4
JournalEuropean Neurology
Volume70
Issue number1-2
DOIs
Publication statusPublished - 1 Aug 2013

Keywords

  • Multiple sclerosis
  • Neuromyelitis optica
  • Spinal cord

Cite this

Liu, Yaou ; Han, Yue ; Duan, Yunyun ; Huang, Jing ; Ren, Zhuoqiong ; Butzkueven, Helmut ; Li, Kuncheng. / Anti-aquaporin-4 antibody positivity in neuromyelitis optica is associated with lesion activity. In: European Neurology. 2013 ; Vol. 70, No. 1-2. pp. 113-116.
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abstract = "Aims: To assess the demographic, clinical and spinal cord MRI characteristics of clinically definite neuromyelitis optica (NMO) patients for association with anti-aquaporin-4 (AQP4) antibody positivity in Chinese patients. Methods: We recruited 72 consecutive patients with NMO. The clinical assessments, sera and spinal MRI scans were obtained within 1 week after the onset of symptoms of acute myelitis. The statistical significance of potential differences in demographic, clinical and spinal MRI lesion characteristics between the two groups (anti-AQP4 antibody positive vs. negative) was determined using the two-sample t test or Fisher's exact test. Results: Forty-nine patients (49/72, 68.1{\%}) were anti-AQP4 antibody positive and 23 patients (23/72, 31.9{\%}) were anti-AQP4 antibody negative. The only characteristic that was significantly different between the groups was the presence of an enhancing spinal cord lesion (p < 0.001). Conclusion: We found a strong association between serum anti-AQP4 antibody positivity and lesional gadolinium enhancement in patients with clinically definite NMO. These findings support prior evidence that anti-AQP4 antibody could be pathogenic in NMO lesion development.",
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Anti-aquaporin-4 antibody positivity in neuromyelitis optica is associated with lesion activity. / Liu, Yaou; Han, Yue; Duan, Yunyun; Huang, Jing; Ren, Zhuoqiong; Butzkueven, Helmut; Li, Kuncheng.

In: European Neurology, Vol. 70, No. 1-2, 01.08.2013, p. 113-116.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Ren, Zhuoqiong

AU - Butzkueven, Helmut

AU - Li, Kuncheng

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