Projects per year
Abstract
Survival of various immune cell populations has been proposed to preferentially rely on a particular anti-apoptotic BCL-2 family member, for example, naive T cells require BCL-2, while regulatory T cells require MCL-1. Here we examined the survival requirements of multiple immune cell subsets in vitro and in vivo, using both genetic and pharmacological approaches. Our findings support a model in which survival is determined by quantitative participation of multiple anti-apoptotic proteins rather than by a single anti-apoptotic protein. This model provides both an insight into how the sum of relative levels of anti-apoptotic proteins BCL-2, MCL-1 and A1 influence survival of T cells, B cells and dendritic cells, and a framework for ascertaining how these different immune cells can be optimally targeted in treatment of immunopathology, transplantation rejection or hematological cancers.
Original language | English |
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Pages (from-to) | 878-888 |
Number of pages | 11 |
Journal | Cell Death and Differentiation |
Volume | 24 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1 May 2017 |
Projects
- 4 Finished
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NHMRC Principal Research Fellowship
National Health and Medical Research Council (NHMRC) (Australia)
11/01/16 → 31/12/19
Project: Research
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The axis of Bcl-2, plasmacytoid DCs and lupus as a basis for therapy
Morand, E. & Lew, A.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/16 → 31/12/18
Project: Research
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A Systems Approach to the Adaptive Immune Response
Hodgkin, P. D., Corcoran, L. M., Tarlinton, D., Belz, G. T. & Nutt, S. L.
1/01/14 → 31/12/18
Project: Research