Anti- and pro-oxidant properties of essential oils against antimicrobial resistance

Amanda Shen-Yee Kong; Sathiya Maran; Polly Soo-Xi Yap; Swee-Hua Erin Lim; Shun-Kai Yang; Wan-Hee Cheng; Yong-Hui Tan; Kok-Song Lai

doi:10.3390/antiox11091819

Anti- and pro-oxidant properties of essential oils against antimicrobial resistance

Amanda Shen-Yee Kong, Sathiya Maran, Polly Soo-Xi Yap, Swee-Hua Erin Lim, Shun-Kai Yang, Wan-Hee Cheng, Yong-Hui Tan, Kok-Song Lai

Research output: Contribution to journal › Review Article › Research › peer-review

2 Citations (Scopus)

Abstract

The rapid evolution of antimicrobial resistance (AMR) has remained a major public health issue, reducing the efficacy of antibiotics and increasing the difficulty of treating infections. The discovery of novel antimicrobial agents is urgently needed to overcome the challenges created by AMR. Natural products such as plant extracts and essential oils (EOs) have been viewed as potential candidates to combat AMR due to their complex chemistry that carries inherent pro-oxidant and antioxidant properties. EOs and their constituents that hold pro-oxidant properties can induce oxidative stress by producing reactive oxygen species (ROS), leading to biological damage in target cells. In contrast, the antioxidant properties scavenge free radicals through offsetting ROS. Both pro-oxidant and antioxidant activities in EOs represent a promising strategy to tackle AMR. Thus, this review aimed to discuss how pro-oxidants and antioxidants in EOs may contribute to the mitigation of AMR and provided a detailed description of the challenges and limitations of utilizing them as a means to combat AMR.

Original language	English
Article number	1819
Number of pages	12
Journal	Antioxidants
Volume	11
Issue number	9
DOIs	https://doi.org/10.3390/antiox11091819
Publication status	Published - Sep 2022

Keywords

antimicrobial resistance
antioxidant
essential oil
pro-oxidant
ROS

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/antiox11091819Licence: CC BY

406785582-oaFinal published version, 641 KBLicence: CC BY

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title = "Anti- and pro-oxidant properties of essential oils against antimicrobial resistance",

abstract = "The rapid evolution of antimicrobial resistance (AMR) has remained a major public health issue, reducing the efficacy of antibiotics and increasing the difficulty of treating infections. The discovery of novel antimicrobial agents is urgently needed to overcome the challenges created by AMR. Natural products such as plant extracts and essential oils (EOs) have been viewed as potential candidates to combat AMR due to their complex chemistry that carries inherent pro-oxidant and antioxidant properties. EOs and their constituents that hold pro-oxidant properties can induce oxidative stress by producing reactive oxygen species (ROS), leading to biological damage in target cells. In contrast, the antioxidant properties scavenge free radicals through offsetting ROS. Both pro-oxidant and antioxidant activities in EOs represent a promising strategy to tackle AMR. Thus, this review aimed to discuss how pro-oxidants and antioxidants in EOs may contribute to the mitigation of AMR and provided a detailed description of the challenges and limitations of utilizing them as a means to combat AMR.",

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AU - Kong, Amanda Shen-Yee

AU - Maran, Sathiya

AU - Yap, Polly Soo-Xi

AU - Lim, Swee-Hua Erin

AU - Yang, Shun-Kai

AU - Cheng, Wan-Hee

AU - Tan, Yong-Hui

AU - Lai, Kok-Song

N1 - Funding Information: This work was funded by the UCSI University Research Excellence & Innovation Grant (REIG-FAS-2020/043) and Interdisciplinary Research Grant from the Higher Colleges of Technology (Interdisciplinary_212322). Publisher Copyright: © 2022 by the authors.

PY - 2022/9

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N2 - The rapid evolution of antimicrobial resistance (AMR) has remained a major public health issue, reducing the efficacy of antibiotics and increasing the difficulty of treating infections. The discovery of novel antimicrobial agents is urgently needed to overcome the challenges created by AMR. Natural products such as plant extracts and essential oils (EOs) have been viewed as potential candidates to combat AMR due to their complex chemistry that carries inherent pro-oxidant and antioxidant properties. EOs and their constituents that hold pro-oxidant properties can induce oxidative stress by producing reactive oxygen species (ROS), leading to biological damage in target cells. In contrast, the antioxidant properties scavenge free radicals through offsetting ROS. Both pro-oxidant and antioxidant activities in EOs represent a promising strategy to tackle AMR. Thus, this review aimed to discuss how pro-oxidants and antioxidants in EOs may contribute to the mitigation of AMR and provided a detailed description of the challenges and limitations of utilizing them as a means to combat AMR.

AB - The rapid evolution of antimicrobial resistance (AMR) has remained a major public health issue, reducing the efficacy of antibiotics and increasing the difficulty of treating infections. The discovery of novel antimicrobial agents is urgently needed to overcome the challenges created by AMR. Natural products such as plant extracts and essential oils (EOs) have been viewed as potential candidates to combat AMR due to their complex chemistry that carries inherent pro-oxidant and antioxidant properties. EOs and their constituents that hold pro-oxidant properties can induce oxidative stress by producing reactive oxygen species (ROS), leading to biological damage in target cells. In contrast, the antioxidant properties scavenge free radicals through offsetting ROS. Both pro-oxidant and antioxidant activities in EOs represent a promising strategy to tackle AMR. Thus, this review aimed to discuss how pro-oxidants and antioxidants in EOs may contribute to the mitigation of AMR and provided a detailed description of the challenges and limitations of utilizing them as a means to combat AMR.

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KW - ROS

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JF - Antioxidants

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ER -

Anti- and pro-oxidant properties of essential oils against antimicrobial resistance

Abstract

Keywords

UN SDGs

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