TY - JOUR
T1 - Anthropometry and head and neck cancer
T2 - A pooled analysis of cohort data
AU - Gaudet, Mia M
AU - Kitahara, Cari M.
AU - Newton, Christina C.
AU - Bernstein, Leslie
AU - Reynolds, Peggy
AU - Weiderpass, Elisabete
AU - Kreimer, Aimée R.
AU - Yang, Gong
AU - Adami, Hans Olov
AU - Alavanja, Michael C.
AU - Beane Freeman, Laura E.
AU - Boeing, Heiner
AU - Buring, Julie E
AU - Chaturvedi, Anil
AU - Chen, Yu
AU - D'Aloisio, Aimee A.
AU - Freedman, Michal
AU - Gao, Yu-Tang
AU - Gaziano, J. Michael
AU - Giles, Graham G.
AU - Håkansson, Niclas
AU - Huang, Wen Yi
AU - Lee, I-Min
AU - Linet, Martha S.
AU - MacInnis, Robert J.
AU - Park, Yikyung
AU - Prizment, Anna
AU - Purdue, Mark P.
AU - Riboli, Elio B
AU - Robien, Kim
AU - Sandler, Dale P.
AU - Schairer, Catherine
AU - Sesso, Howard D.
AU - Shu, Xiao-Ou
AU - White, Emily
AU - Wolk, Alicja
AU - Xiang, Yong-Bing
AU - Zelenuich-Jacquotte, Anne
AU - Zheng, Wei
AU - Patel, Alpa V.
AU - Hartge, Patricia
AU - De González, Amy Berrington
AU - Gapstur, Susan M.
PY - 2015/6/6
Y1 - 2015/6/6
N2 - Background: Associations between anthropometry and head and neck cancer (HNC) risk are inconsistent. We aimed to evaluate these associations while minimizing biases found in previous studies. Methods: We pooled data from 1 941 300 participants, including 3760 cases, in 20 cohort studies and used multivariable-adjusted Cox proportional hazard regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association of anthropometric measures with HNC risk overall and stratified by smoking status. Results: Greater waist circumference (per 5cm: HR = 1.04, 95% CI 1.03-1.05, P-value for trend = < 0.0001) and waist-to-hip ratio (per 0.1 unit: HR = 1.07, 95% CI 1.05-1.09, P-value for trend = < 0.0001), adjusted for body mass index (BMI), were associated with higher risk and did not vary by smoking status (P-value for heterogeneity = 0.85 and 0.44, respectively). Associations with BMI (P-value for interaction = < 0.0001) varied by smoking status. Larger BMI was associated with higher HNC risk in never smokers (per 5 kg/m2: HR = 1.15, 95% CI 1.06-1.24, P-value for trend = 0.0006), but not in former smokers (per 5 kg/m2: HR = 0.99, 95% CI 0.93-1.06, P-value for trend = 0.79) or current smokers (per 5 kg/m2: HR = 0.76, 95% CI 0.71-0.82, P-value for trend = < 0.0001). Larger hip circumference was not associated with a higher HNC risk. Greater height (per 5cm) was associated with higher risk of HNC in never and former smokers, but not in current smokers. Conclusions: Waist circumference and waist-to-hip ratio were associated positively with HNC risk regardless of smoking status, whereas a positive association with BMI was only found in never smokers.
AB - Background: Associations between anthropometry and head and neck cancer (HNC) risk are inconsistent. We aimed to evaluate these associations while minimizing biases found in previous studies. Methods: We pooled data from 1 941 300 participants, including 3760 cases, in 20 cohort studies and used multivariable-adjusted Cox proportional hazard regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association of anthropometric measures with HNC risk overall and stratified by smoking status. Results: Greater waist circumference (per 5cm: HR = 1.04, 95% CI 1.03-1.05, P-value for trend = < 0.0001) and waist-to-hip ratio (per 0.1 unit: HR = 1.07, 95% CI 1.05-1.09, P-value for trend = < 0.0001), adjusted for body mass index (BMI), were associated with higher risk and did not vary by smoking status (P-value for heterogeneity = 0.85 and 0.44, respectively). Associations with BMI (P-value for interaction = < 0.0001) varied by smoking status. Larger BMI was associated with higher HNC risk in never smokers (per 5 kg/m2: HR = 1.15, 95% CI 1.06-1.24, P-value for trend = 0.0006), but not in former smokers (per 5 kg/m2: HR = 0.99, 95% CI 0.93-1.06, P-value for trend = 0.79) or current smokers (per 5 kg/m2: HR = 0.76, 95% CI 0.71-0.82, P-value for trend = < 0.0001). Larger hip circumference was not associated with a higher HNC risk. Greater height (per 5cm) was associated with higher risk of HNC in never and former smokers, but not in current smokers. Conclusions: Waist circumference and waist-to-hip ratio were associated positively with HNC risk regardless of smoking status, whereas a positive association with BMI was only found in never smokers.
KW - Head and neck neoplasms
KW - Obesity
KW - Smoking
KW - Waist circumference
KW - Waist-hip ratio
UR - http://www.scopus.com/inward/record.url?scp=84936746191&partnerID=8YFLogxK
U2 - 10.1093/ije/dyv059
DO - 10.1093/ije/dyv059
M3 - Article
C2 - 26050257
AN - SCOPUS:84936746191
SN - 0300-5771
VL - 44
SP - 673
EP - 681
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
IS - 2
ER -
