Anthracene-modified oligonucleotides as fluorescent DNA mismatch sensors: Discrimination between various base-pair mismatches

Jean Louis H.A. Duprey; Dario M. Bassani; Eva I. Hyde; Christian Ludwig; Alison Rodger; Joseph S. Vyle; John S Wilkie; Zheng-Yun Zhao; James H.R. Tucker

doi:10.1080/10610278.2010.523117

Anthracene-modified oligonucleotides as fluorescent DNA mismatch sensors: Discrimination between various base-pair mismatches

Jean Louis H.A. Duprey, Dario M. Bassani, Eva I. Hyde, Christian Ludwig, Alison Rodger, Joseph S. Vyle, John S Wilkie, Zheng-Yun Zhao, James H.R. Tucker

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Abstract

A fluorescent anthracene-tagged DNA probe has been shown to respond to various DNA sequences by changes to its emission signal upon duplex formation. The fluorescence response for duplexes containing a single mismatch near the anthracene site has been found to be very sensitive to its composition, with the emission signal increasing for a CA mismatch and decreasing for CT and CC mismatches.

Original language	English
Pages (from-to)	273-277
Number of pages	5
Journal	Supramolecular Chemistry
Volume	23
Issue number	3-4
DOIs	https://doi.org/10.1080/10610278.2010.523117
Publication status	Published - Mar 2011
Externally published	Yes

Keywords

Anthracene
DNA
Fluorescence
Sensor
SNP

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10.1080/10610278.2010.523117Licence: Unspecified

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abstract = "A fluorescent anthracene-tagged DNA probe has been shown to respond to various DNA sequences by changes to its emission signal upon duplex formation. The fluorescence response for duplexes containing a single mismatch near the anthracene site has been found to be very sensitive to its composition, with the emission signal increasing for a CA mismatch and decreasing for CT and CC mismatches.",

keywords = "Anthracene, DNA, Fluorescence, Sensor, SNP",

author = "Duprey, {Jean Louis H.A.} and Bassani, {Dario M.} and Hyde, {Eva I.} and Christian Ludwig and Alison Rodger and Vyle, {Joseph S.} and Wilkie, {John S} and Zheng-Yun Zhao and Tucker, {James H.R.}",

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AU - Duprey, Jean Louis H.A.

AU - Bassani, Dario M.

AU - Hyde, Eva I.

AU - Ludwig, Christian

AU - Rodger, Alison

AU - Vyle, Joseph S.

AU - Wilkie, John S

AU - Zhao, Zheng-Yun

AU - Tucker, James H.R.

PY - 2011/3

Y1 - 2011/3

N2 - A fluorescent anthracene-tagged DNA probe has been shown to respond to various DNA sequences by changes to its emission signal upon duplex formation. The fluorescence response for duplexes containing a single mismatch near the anthracene site has been found to be very sensitive to its composition, with the emission signal increasing for a CA mismatch and decreasing for CT and CC mismatches.

AB - A fluorescent anthracene-tagged DNA probe has been shown to respond to various DNA sequences by changes to its emission signal upon duplex formation. The fluorescence response for duplexes containing a single mismatch near the anthracene site has been found to be very sensitive to its composition, with the emission signal increasing for a CA mismatch and decreasing for CT and CC mismatches.

KW - Anthracene

KW - DNA

KW - Fluorescence

KW - Sensor

KW - SNP

UR - http://www.scopus.com/inward/record.url?scp=79956021373&partnerID=8YFLogxK

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DO - 10.1080/10610278.2010.523117

M3 - Article

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JO - Supramolecular Chemistry

JF - Supramolecular Chemistry

IS - 3-4

ER -

Anthracene-modified oligonucleotides as fluorescent DNA mismatch sensors: Discrimination between various base-pair mismatches

Abstract

Keywords

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