Antenatal serum levels of relaxin in patients having preterm labour

ROBIN J. BELL, LAWRENCE W. EDDIE, ARLENE R. LESTER, E. CARL WOOD, PAUL D. JOHNSTON, HUGH D. NIALL

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Abstract

Summary. This study is the first report of antenatal levels of relaxin measured by homologous radioimmunoassay in peripheral serum from patients who subsequently had a preterm delivery. Serial blood samples were collected antenatally from a group of subjects known to be at increased risk of preterm labour because of a past history of shortened pregnancy. Serum relaxin was measured using an homologous radioimmunoassay based on a synthetic bioactive analogoue of the native hormone. In women whose pregnancies ended preterm most measurements were within the range of values previously established in normal antenatal patients although some measurements early in pregnancy were above the normal range. These findings suggest that low serum levels of relaxin are not causatively related to the onset of labour before term.

Original languageEnglish
Pages (from-to)1264-1267
Number of pages4
JournalBritish Journal of Obstetrics and Gynaecology
Volume95
Issue number12
DOIs
Publication statusPublished - 1 Jan 1988
Externally publishedYes

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