Background Cytomegalovirus (CMV) is a herpesvirus and themost common cause of congenital infection in developed countries. Congenital CMV infection can have devastating consequences to the fetus. The high incidence and the serious morbidity associated with congenital CMV infection emphasise the need for effective interventions to prevent the antenatal transmission of CMV infection. Objectives The aim of this review was to assess the benefits and harms of interventions used during pregnancy to prevent mother to fetus transmission of CMV infection. Search strategy We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 December 2010). Selection criteria All randomised controlled trials (RCTs) and quasi RCTs investigating antenatal interventions for preventing the transmission of CMV from the mother to fetus during pregnancy and adverse outcomes in the congenitally infected infant. Data collection and analysis Two review authors independently assessed studies for inclusion. Main results We identified six studies from the search. None of these studies met the pre-defined criteria for inclusion in this review.