Antenatal glucocorticoids reduce growth in appropriately grown and growth-restricted ovine fetuses in a sex-specific manner

Suzanne Lee Miller, Amy Elizabeth Sutherland, Veena Gayathri Supramaniam, David William Walker, Graham Jenkin, Euan Morrison Wallace

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

Antenatal glucocorticoids are administered to mature the fetal lungs before preterm birth. Glucocorticoids also have non-pulmonary effects, including reducing fetal body and brain growth. The present study examined whether glucocorticoid administration has a sex-specific effect on growth in appropriately grown (control) and intrauterine growth-restricted (IUGR) fetal sheep. IUGR was induced at 0.7 gestation in fetal sheep by single umbilical artery ligation. On Days 5 and 6 after surgery, IUGR or control fetuses were exposed to the synthetic glucocorticoid betamethasone (BM; 11.4mg) or saline via intramuscular maternal administration. On Day 7, a postmortem was conducted to determine fetal sex and weight. Compared with control fetuses, the birthweight of male and female IUGR fetuses was significantly reduced (by 18.5+/-4.4 (P=0.002) and 21.7+/-6.0 (P=0.001), respectively). Maternal administration of BM significantly reduced bodyweight in both control and IUGR fetuses (by 11.3+/-2.8 and 20.5+/-3.6 in control male and female fetuses, respectively; and by 22.9+/-3.1 and 38.3+/-3.4 in IUGR male and female fetuses, respectively; P
Original languageEnglish
Pages (from-to)753 - 758
Number of pages6
JournalReproduction, Fertility and Development
Volume24
Issue number5
DOIs
Publication statusPublished - 2012

Cite this

@article{3f908c2f6e0a4df08c2336e11cea8b85,
title = "Antenatal glucocorticoids reduce growth in appropriately grown and growth-restricted ovine fetuses in a sex-specific manner",
abstract = "Antenatal glucocorticoids are administered to mature the fetal lungs before preterm birth. Glucocorticoids also have non-pulmonary effects, including reducing fetal body and brain growth. The present study examined whether glucocorticoid administration has a sex-specific effect on growth in appropriately grown (control) and intrauterine growth-restricted (IUGR) fetal sheep. IUGR was induced at 0.7 gestation in fetal sheep by single umbilical artery ligation. On Days 5 and 6 after surgery, IUGR or control fetuses were exposed to the synthetic glucocorticoid betamethasone (BM; 11.4mg) or saline via intramuscular maternal administration. On Day 7, a postmortem was conducted to determine fetal sex and weight. Compared with control fetuses, the birthweight of male and female IUGR fetuses was significantly reduced (by 18.5+/-4.4 (P=0.002) and 21.7+/-6.0 (P=0.001), respectively). Maternal administration of BM significantly reduced bodyweight in both control and IUGR fetuses (by 11.3+/-2.8 and 20.5+/-3.6 in control male and female fetuses, respectively; and by 22.9+/-3.1 and 38.3+/-3.4 in IUGR male and female fetuses, respectively; P",
author = "Miller, {Suzanne Lee} and Sutherland, {Amy Elizabeth} and Supramaniam, {Veena Gayathri} and Walker, {David William} and Graham Jenkin and Wallace, {Euan Morrison}",
year = "2012",
doi = "10.1071/RD11143",
language = "English",
volume = "24",
pages = "753 -- 758",
journal = "Reproduction, Fertility and Development",
issn = "1031-3613",
publisher = "CSIRO",
number = "5",

}

Antenatal glucocorticoids reduce growth in appropriately grown and growth-restricted ovine fetuses in a sex-specific manner. / Miller, Suzanne Lee; Sutherland, Amy Elizabeth; Supramaniam, Veena Gayathri; Walker, David William; Jenkin, Graham; Wallace, Euan Morrison.

In: Reproduction, Fertility and Development, Vol. 24, No. 5, 2012, p. 753 - 758.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Antenatal glucocorticoids reduce growth in appropriately grown and growth-restricted ovine fetuses in a sex-specific manner

AU - Miller, Suzanne Lee

AU - Sutherland, Amy Elizabeth

AU - Supramaniam, Veena Gayathri

AU - Walker, David William

AU - Jenkin, Graham

AU - Wallace, Euan Morrison

PY - 2012

Y1 - 2012

N2 - Antenatal glucocorticoids are administered to mature the fetal lungs before preterm birth. Glucocorticoids also have non-pulmonary effects, including reducing fetal body and brain growth. The present study examined whether glucocorticoid administration has a sex-specific effect on growth in appropriately grown (control) and intrauterine growth-restricted (IUGR) fetal sheep. IUGR was induced at 0.7 gestation in fetal sheep by single umbilical artery ligation. On Days 5 and 6 after surgery, IUGR or control fetuses were exposed to the synthetic glucocorticoid betamethasone (BM; 11.4mg) or saline via intramuscular maternal administration. On Day 7, a postmortem was conducted to determine fetal sex and weight. Compared with control fetuses, the birthweight of male and female IUGR fetuses was significantly reduced (by 18.5+/-4.4 (P=0.002) and 21.7+/-6.0 (P=0.001), respectively). Maternal administration of BM significantly reduced bodyweight in both control and IUGR fetuses (by 11.3+/-2.8 and 20.5+/-3.6 in control male and female fetuses, respectively; and by 22.9+/-3.1 and 38.3+/-3.4 in IUGR male and female fetuses, respectively; P

AB - Antenatal glucocorticoids are administered to mature the fetal lungs before preterm birth. Glucocorticoids also have non-pulmonary effects, including reducing fetal body and brain growth. The present study examined whether glucocorticoid administration has a sex-specific effect on growth in appropriately grown (control) and intrauterine growth-restricted (IUGR) fetal sheep. IUGR was induced at 0.7 gestation in fetal sheep by single umbilical artery ligation. On Days 5 and 6 after surgery, IUGR or control fetuses were exposed to the synthetic glucocorticoid betamethasone (BM; 11.4mg) or saline via intramuscular maternal administration. On Day 7, a postmortem was conducted to determine fetal sex and weight. Compared with control fetuses, the birthweight of male and female IUGR fetuses was significantly reduced (by 18.5+/-4.4 (P=0.002) and 21.7+/-6.0 (P=0.001), respectively). Maternal administration of BM significantly reduced bodyweight in both control and IUGR fetuses (by 11.3+/-2.8 and 20.5+/-3.6 in control male and female fetuses, respectively; and by 22.9+/-3.1 and 38.3+/-3.4 in IUGR male and female fetuses, respectively; P

UR - http://www.publish.csiro.au/?act=view_file&file_id=RD11143.pdf

U2 - 10.1071/RD11143

DO - 10.1071/RD11143

M3 - Article

VL - 24

SP - 753

EP - 758

JO - Reproduction, Fertility and Development

JF - Reproduction, Fertility and Development

SN - 1031-3613

IS - 5

ER -