TY - JOUR
T1 - Annotated draft genomic sequence from a Streptococcus pneumoniae type 19F clinical isolate
AU - Dopazo, J.
AU - Mendoza, A.
AU - Herrero, J.
AU - Caldara, F.
AU - Humbert, Y.
AU - Friedli, L.
AU - Guerrier, M.
AU - Grand-Schenk, E.
AU - Gandin, C.
AU - De Francesco, M.
AU - Polissi, A.
AU - Buell, G.
AU - Feger, G.
AU - García, E.
AU - Peitsch, M.
AU - García-Bustos, J. F.
PY - 2001/7/7
Y1 - 2001/7/7
N2 - The public availability of numerous microbial genomes is enabling the analysis of bacterial biology in great detail and with an unprecedented, organism-wide and taxon-wide, broad scope. Streptococcus pneumoniae is one of the most important bacterial pathogens throughout the world. We present here sequences and functional annotations for 2.1-Mbp of pneumococcal DNA, covering more than 90% of the total estimated size of the genome. The sequenced strain is a clinical isolate resistant to macrolides and tetracycline. It carries a type 19F capsular locus, but multilocus sequence typing for several conserved genetic loci suggests that the strain sequenced belongs to a pneumococcal lineage that most often expresses a serotype 15 capsular polysaccharide. A total of 2,046 putative open reading frames (ORFs) longer than 100 amino acids were identified (average of 1,009 bp per ORF), including all described two-component systems and aminoacyl tRNA synthetases. Comparisons to other complete, or nearly complete, bacterial genomes were made and are presented in a graphical form for all the predicted proteins.
AB - The public availability of numerous microbial genomes is enabling the analysis of bacterial biology in great detail and with an unprecedented, organism-wide and taxon-wide, broad scope. Streptococcus pneumoniae is one of the most important bacterial pathogens throughout the world. We present here sequences and functional annotations for 2.1-Mbp of pneumococcal DNA, covering more than 90% of the total estimated size of the genome. The sequenced strain is a clinical isolate resistant to macrolides and tetracycline. It carries a type 19F capsular locus, but multilocus sequence typing for several conserved genetic loci suggests that the strain sequenced belongs to a pneumococcal lineage that most often expresses a serotype 15 capsular polysaccharide. A total of 2,046 putative open reading frames (ORFs) longer than 100 amino acids were identified (average of 1,009 bp per ORF), including all described two-component systems and aminoacyl tRNA synthetases. Comparisons to other complete, or nearly complete, bacterial genomes were made and are presented in a graphical form for all the predicted proteins.
UR - http://www.scopus.com/inward/record.url?scp=0034961107&partnerID=8YFLogxK
M3 - Article
C2 - 11442348
AN - SCOPUS:0034961107
VL - 7
SP - 99
EP - 126
JO - Microbial Drug Resistance
JF - Microbial Drug Resistance
SN - 1076-6294
IS - 2
ER -