Animal models of preeclampsia: Translational failings and why

Sarah A. Marshall, Natalie J. Hannan, Maria Jelinic, Thy P.H. Nguyen, Jane E. Girling, Laura J. Parry

Research output: Contribution to journalReview ArticleOtherpeer-review

48 Citations (Scopus)

Abstract

Preeclampsia affects up to 8% of pregnancies worldwide and is a leading cause of both maternal and fetal morbidity and mortality. Our current understanding of the cause(s) of preeclampsia is far from complete, and the lack of a single reliable animal model that recapitulates all aspects of the disease further confounds our understanding. This is partially due to the heterogeneous nature of the disease, coupled with our evolving understanding of its etiology. Nevertheless, animal models are still highly relevant and useful tools that help us better understand the pathophysiology of specific aspects of preeclampsia. This review summarizes the various types and characteristics of animal models used to study preeclampsia, highlighting particular features of these models relevant to clinical translation. This review points out the strengths and limitations of these models to illustrate the importance of using the appropriate model depending on the research question.

Original languageEnglish
Pages (from-to)R499-R508
Number of pages10
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume314
Issue number4
DOIs
Publication statusPublished - 1 Apr 2018
Externally publishedYes

Keywords

  • Animal models
  • Preeclampsia
  • Translational failings

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