Animal models for studying dengue pathogenesis and therapy

Kitti Wing Ki Chan, Satoru Watanabe, Ranmali Kavishna, Sylvie Alonso, Subhash G. Vasudevan

Research output: Contribution to journalReview ArticleOtherpeer-review

59 Citations (Scopus)

Abstract

Development of a suitable animal model for dengue virus disease is critical for understanding pathogenesis and for preclinical testing of antiviral drugs and vaccines. Many laboratory animal models of dengue virus infection have been investigated, but the challenges of recapitulating the complete disease still remain. In this review, we provide a comprehensive coverage of existing models, from man to mouse, with a specific focus on recent advances in mouse models for addressing the mechanistic aspects of severe dengue in humans. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.

Original languageEnglish
Pages (from-to)5-14
Number of pages10
JournalAntiviral Research
Volume123
DOIs
Publication statusPublished - Nov 2015
Externally publishedYes

Keywords

  • AG129 mice
  • Animal models
  • Antiviral therapy
  • Dengue
  • Dengue hemorrhagic fever

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