Animal models for studying coronavirus infections and developing antiviral agents and vaccines

Qisheng Lin; Chunni Lu; Yuqi Hong; Runfeng Li; Jinding Chen; Weisan Chen; Jianxin Chen

doi:10.1016/j.antiviral.2022.105345

Animal models for studying coronavirus infections and developing antiviral agents and vaccines

Qisheng Lin, Chunni Lu, Yuqi Hong, Runfeng Li, Jinding Chen, Weisan Chen, Jianxin Chen

Research output: Contribution to journal › Review Article › Research › peer-review

8 Citations (Scopus)

Abstract

In addition to severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV-2 has become the third deadly coronavirus that infects humans and causes the new coronavirus disease (COVID-19). COVID-19 has already caused more than six million deaths worldwide and it is likely the biggest pandemic of this century faced by mankind. Although many studies on SARS-CoV-2 have been conducted, a detailed understanding of SARS-CoV-2 and COVID-19 is still lacking. Animal models are indispensable for studying its pathogenesis and developing vaccines and antivirals. In this review, we analyze animal models of coronavirus infections and explore their applications on antivirals and vaccines.

Original language	English
Article number	105345
Number of pages	23
Journal	Antiviral Research
Volume	203
DOIs	https://doi.org/10.1016/j.antiviral.2022.105345
Publication status	Published - Jul 2022

Keywords

Animal models
Antiviral agent
Coronavirus
SARS-CoV-2
Vaccine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.antiviral.2022.105345

Cite this

@article{66eee2d1ae2c4f51988a8d9703e2ae09,

title = "Animal models for studying coronavirus infections and developing antiviral agents and vaccines",

abstract = "In addition to severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV-2 has become the third deadly coronavirus that infects humans and causes the new coronavirus disease (COVID-19). COVID-19 has already caused more than six million deaths worldwide and it is likely the biggest pandemic of this century faced by mankind. Although many studies on SARS-CoV-2 have been conducted, a detailed understanding of SARS-CoV-2 and COVID-19 is still lacking. Animal models are indispensable for studying its pathogenesis and developing vaccines and antivirals. In this review, we analyze animal models of coronavirus infections and explore their applications on antivirals and vaccines.",

keywords = "Animal models, Antiviral agent, Coronavirus, SARS-CoV-2, Vaccine",

author = "Qisheng Lin and Chunni Lu and Yuqi Hong and Runfeng Li and Jinding Chen and Weisan Chen and Jianxin Chen",

note = "Funding Information: This work was supported by the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (Grant, 2019BT02N054 ), the Emergency Project of the Department of Agriculture and Rural Affairs of Guangdong Province for Tackling Key Scientific and Technological Problems of 2019-nCoV Pneumonia, and Special Technologies R&D Program for COVID-19 of Guangdong Province (Grant, 2020A111128014 ). Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2022",

month = jul,

doi = "10.1016/j.antiviral.2022.105345",

language = "English",

volume = "203",

journal = "Antiviral Research",

issn = "0166-3542",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Animal models for studying coronavirus infections and developing antiviral agents and vaccines

AU - Lin, Qisheng

AU - Lu, Chunni

AU - Hong, Yuqi

AU - Li, Runfeng

AU - Chen, Jinding

AU - Chen, Weisan

AU - Chen, Jianxin

N1 - Funding Information: This work was supported by the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (Grant, 2019BT02N054 ), the Emergency Project of the Department of Agriculture and Rural Affairs of Guangdong Province for Tackling Key Scientific and Technological Problems of 2019-nCoV Pneumonia, and Special Technologies R&D Program for COVID-19 of Guangdong Province (Grant, 2020A111128014 ). Publisher Copyright: © 2022 Elsevier B.V.

PY - 2022/7

Y1 - 2022/7

N2 - In addition to severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV-2 has become the third deadly coronavirus that infects humans and causes the new coronavirus disease (COVID-19). COVID-19 has already caused more than six million deaths worldwide and it is likely the biggest pandemic of this century faced by mankind. Although many studies on SARS-CoV-2 have been conducted, a detailed understanding of SARS-CoV-2 and COVID-19 is still lacking. Animal models are indispensable for studying its pathogenesis and developing vaccines and antivirals. In this review, we analyze animal models of coronavirus infections and explore their applications on antivirals and vaccines.

AB - In addition to severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV-2 has become the third deadly coronavirus that infects humans and causes the new coronavirus disease (COVID-19). COVID-19 has already caused more than six million deaths worldwide and it is likely the biggest pandemic of this century faced by mankind. Although many studies on SARS-CoV-2 have been conducted, a detailed understanding of SARS-CoV-2 and COVID-19 is still lacking. Animal models are indispensable for studying its pathogenesis and developing vaccines and antivirals. In this review, we analyze animal models of coronavirus infections and explore their applications on antivirals and vaccines.

KW - Animal models

KW - Antiviral agent

KW - Coronavirus

KW - SARS-CoV-2

KW - Vaccine

UR - http://www.scopus.com/inward/record.url?scp=85130874981&partnerID=8YFLogxK

U2 - 10.1016/j.antiviral.2022.105345

DO - 10.1016/j.antiviral.2022.105345

M3 - Review Article

C2 - 35605699

AN - SCOPUS:85130874981

SN - 0166-3542

VL - 203

JO - Antiviral Research

JF - Antiviral Research

M1 - 105345

ER -

Animal models for studying coronavirus infections and developing antiviral agents and vaccines

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Cite this