Animal models for studying coronavirus infections and developing antiviral agents and vaccines

Qisheng Lin, Chunni Lu, Yuqi Hong, Runfeng Li, Jinding Chen, Weisan Chen, Jianxin Chen

Research output: Contribution to journalReview ArticleResearchpeer-review

7 Citations (Scopus)


In addition to severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV-2 has become the third deadly coronavirus that infects humans and causes the new coronavirus disease (COVID-19). COVID-19 has already caused more than six million deaths worldwide and it is likely the biggest pandemic of this century faced by mankind. Although many studies on SARS-CoV-2 have been conducted, a detailed understanding of SARS-CoV-2 and COVID-19 is still lacking. Animal models are indispensable for studying its pathogenesis and developing vaccines and antivirals. In this review, we analyze animal models of coronavirus infections and explore their applications on antivirals and vaccines.

Original languageEnglish
Article number105345
Number of pages23
JournalAntiviral Research
Publication statusPublished - Jul 2022


  • Animal models
  • Antiviral agent
  • Coronavirus
  • SARS-CoV-2
  • Vaccine

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