Animal Models for Manipulation of Thermogenesis

John Paul Fuller-Jackson, Iain J. Clarke, Belinda A. Henry

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

Abstract

Body weight is determined by the balance between energy intake and energy expenditure. Energy expenditure is comprised of four major facets, including basal metabolic rate, physical activity, nonexercise activity thermogenesis, and adaptive thermogenesis. This chapter discusses the role of energy expenditure and, in particular, adaptive thermogenesis in the control of body weight. Adaptive thermogenesis occurs via futile cellular cycles in response to both cold and dietary stimuli. This process occurs in brown adipose tissue (BAT), beige adipocytes, and skeletal muscle. This chapter highlights the differential contribution of adipose and muscle thermogenesis to the development of obesity in a variety of animal models. In this regard, large animal models have been particularly useful in delineating the roles of BAT and skeletal muscle in the control of body weight.

Original languageEnglish
Title of host publicationAnimal Models for the Study of Human Disease
EditorsP. Michael Conn
Place of PublicationLondon UK
PublisherAcademic Press
Chapter12
Pages281-312
Number of pages32
Edition2nd
ISBN (Electronic)9780124158948
ISBN (Print)9780128094686
DOIs
Publication statusPublished - 28 Jun 2017

Keywords

  • Beige adipocytes
  • Brown adipocytes
  • Energy expenditure
  • Season and obesity
  • Skeletal muscle
  • Stress-responsiveness
  • Sympathetic nervous system
  • Thermogenesis

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