Angiotensin type 2 receptor stimulation increases renal function in female, but not male, spontaneously hypertensive rats

Lucinda M Hilliard, Charis L E Chow, Katrina M Mirabito, U Muscha Steckelings, Thomas Unger, Robert E Widdop, Katherine M Denton

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48 Citations (Scopus)

Abstract

Accumulating evidence suggests that the protective pathways of the renin-angiotensin system are enhanced in women, including the angiotensin type 2 receptor (AT2R), which mediates vasodilatory and natriuretic effects. To provide insight into the sex-specific ability of pharmacological AT2R stimulation to modulate renal function in hypertension, we examined the influence of the AT2R agonist, compound 21 (100-300 ng/kg per minute), on renal function in 18- to 19-week-old anesthetized male and female spontaneously hypertensive rats. AT2R stimulation significantly increased renal blood flow in female hypertensive rats (PTreatment
Original languageEnglish
Pages (from-to)378 - 383
Number of pages6
JournalHypertension
Volume64
Issue number2
DOIs
Publication statusPublished - 2014

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