Angiotensin receptor neprilysin inhibitor LCZ696: Pharmacology, pharmacokinetics and clinical development

Yue Hua, Ian Wang, Bin Liu, Darren J. Kelly, Christopher M. Reid, Danny Liew, Yingchun Zhou, Bing H. Wang

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Heart failure still has a significant disease burden with poor outcomes worldwide despite advances in therapy. The standard therapies have been focused on blockade of renin-angiotensin-aldosterone system with angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and mineralocorticoid antagonists and the sympathetic nervous system with β-blockers. The natriuretic peptide system is a potential counter-regulatory system that promotes vasodilatation and natriuresis. Angiotensin receptor neprilysin inhibitors are a new class drug capable of blocking the renin-angiotensin-aldosterone system and enhancing the natriuretic peptide system to improve neurohormonal balance. The success of the PARADIGM-HF trial with LCZ696 and its approval for heart failure treatment is likely to generate a paradigm shift. This review summarises the current knowledge of LCZ696 with a focus on pharmacology, pharmacokinetics and pharmacodynamics, mechanisms of action, clinical efficacy and safety.

Original languageEnglish
Pages (from-to)103-115
Number of pages13
JournalFuture Cardiology
Volume13
Issue number2
DOIs
Publication statusPublished - 1 Mar 2017

Keywords

  • angiotensin receptor neprilysin inhibitor
  • heart failure
  • neprilysin inhibitor

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