TY - JOUR
T1 - Angiotensin II Type 2 receptor stimulation initiated after stroke causes neuroprotection in conscious rats
AU - McCarthy, Claudia A
AU - Vinh, Antony
AU - Broughton, Bradley RS
AU - Sobey, Christopher G
AU - Callaway, Jennifer Kay
AU - Widdop, Robert E
PY - 2012
Y1 - 2012
N2 - We have demonstrated previously that pretreatment with an angiotensin II type 2 receptor (AT(2)R) agonist is neuroprotective against a subsequent stroke independent of any changes in blood pressure. Therefore, in the current study, we have examined the potential neuroprotective effect of AT(2)R stimulation initiated after stroke induction to mimic the clinical setting. Intracerebroventricular administration of the AT(2)R agonist CGP42112 was commenced 6 hours after an ischemic stroke had been induced in conscious spontaneously hypertensive rats. CGP42112 given over 4 doses in the same rats (3 microg/kg per dose centrally) at 6, 24, 48, and 72 hours after stroke induction reduced total infarct volume (32+/-13 mm(3) versus vehicle, 170+/-49 mm(3); P
AB - We have demonstrated previously that pretreatment with an angiotensin II type 2 receptor (AT(2)R) agonist is neuroprotective against a subsequent stroke independent of any changes in blood pressure. Therefore, in the current study, we have examined the potential neuroprotective effect of AT(2)R stimulation initiated after stroke induction to mimic the clinical setting. Intracerebroventricular administration of the AT(2)R agonist CGP42112 was commenced 6 hours after an ischemic stroke had been induced in conscious spontaneously hypertensive rats. CGP42112 given over 4 doses in the same rats (3 microg/kg per dose centrally) at 6, 24, 48, and 72 hours after stroke induction reduced total infarct volume (32+/-13 mm(3) versus vehicle, 170+/-49 mm(3); P
UR - http://hyper.ahajournals.org/content/60/6/1531.full.pdf
U2 - 10.1161/HYPERTENSIONAHA.112.199646
DO - 10.1161/HYPERTENSIONAHA.112.199646
M3 - Article
SN - 0194-911X
VL - 60
SP - 1531
EP - 1537
JO - Hypertension
JF - Hypertension
IS - 6
ER -