Angiotensin II Type 2 receptor stimulation initiated after stroke causes neuroprotection in conscious rats

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We have demonstrated previously that pretreatment with an angiotensin II type 2 receptor (AT(2)R) agonist is neuroprotective against a subsequent stroke independent of any changes in blood pressure. Therefore, in the current study, we have examined the potential neuroprotective effect of AT(2)R stimulation initiated after stroke induction to mimic the clinical setting. Intracerebroventricular administration of the AT(2)R agonist CGP42112 was commenced 6 hours after an ischemic stroke had been induced in conscious spontaneously hypertensive rats. CGP42112 given over 4 doses in the same rats (3 microg/kg per dose centrally) at 6, 24, 48, and 72 hours after stroke induction reduced total infarct volume (32+/-13 mm(3) versus vehicle, 170+/-49 mm(3); P
Original languageEnglish
Pages (from-to)1531 - 1537
Number of pages7
Issue number6
Publication statusPublished - 2012

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