Angiotensin II receptors and angiotensin converting enzyme in the medulla oblongata

Andrew M. Allen, Siew Yeen Chai, Patrick M. Sexton, Stephen J. Lewis, Anthony J.M. Verberne, Bevyn Jarrott, William J. Louis, Jenny Clevers, Michael J. McKinley, George Paxinos, Frederick A.O. Mendelsohn

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Abstract

Quantitative in vitro autoradiography was used to map angiotensin II (ANG II) receptors and angiotensin converting enzyme (ACE) in sections from rat, rabbit, sheep, and human medulla oblongata and to follow changes in receptor and ACE density after disruption of vagal projections by nodose ganglionectomy in the rat. ANG II receptors and ACE are both concentrated in the nucleus of the solitary tract and dorsal motor nucleus of vagus of the rat, rabbit, sheep, and human. An ANG II receptor-containing band connecting the nucleus of the solitary tract with the dorsolateral medulla was seen in rabbit and human tissue, providing evidence for association of ANG II receptors with vagal afferent fibers. ANG II receptors were found to be concentrated in the rostral and caudal ventrolateral medulla, which corresponded to the region of Cl and Al catecholaminecontaining cell groups in the rabbit. This localization was also evident in rat and human tissue. In all four species, a prominent, ANG II receptor-rich band in the intermediate reticular nucleus was found to connect the ventrolateral medulla and the dorsal vagal complex. In humans and sheep, this band contains puncta that overlie cell bodies. One week after nodose ganglionectomy in the rat, the density of ANG II receptors in the ipsilateral dorsal vagal complex fell markedly. This fall was most prominent in the rostral dorsal motor nucleus of vagus (to 46% of control density) and in the nucleus of the solitary tract (to 56% of control). ACE levels and calcitonin gene-related peptide receptor density were unchanged in both nuclei after ganglionectomy. These studies identified anatomical substrates for interactions of brain ANG II with vagal function, central catecholaminergic systems, and autonomic activity.

Original languageEnglish
Pages (from-to)III-198-III-205
Number of pages8
JournalHypertension
Volume9
Issue number6, Part 2
Publication statusPublished - 1 Jan 1987
Externally publishedYes

Keywords

  • Angiotensin converting enzyme
  • Angiotensin ii
  • Autonomic control
  • Calcitonin gene-related peptide
  • Medulla oblongata
  • Receptors

Cite this

Allen, A. M., Chai, S. Y., Sexton, P. M., Lewis, S. J., Verberne, A. J. M., Jarrott, B., Louis, W. J., Clevers, J., McKinley, M. J., Paxinos, G., & Mendelsohn, F. A. O. (1987). Angiotensin II receptors and angiotensin converting enzyme in the medulla oblongata. Hypertension, 9(6, Part 2), III-198-III-205.