Anemia After Kidney Transplantation Is Not Completely Explained by Reduced Kidney Function

Steven J Chadban, Laura Baines, Kevan R Polkinghorne, Andrew Jefferys, Sharan Dogra, Claire Kanganas, Ashley Irish, Josette M Eris, Rowan G Walker

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Abstract

Background: Anemia is prevalent among kidney transplant recipients and likely contributes to mortality and morbidity. Prevalence of anemia is associated strongly with degree of kidney graft dysfunction; however, it remains unclear whether additional transplant-associated factors also contribute. Methods: The aim of this study is to compare the prevalence of anemia between 2 cohorts, 1 of kidney transplant recipients (n 851) and another from the general population (n 732), sourced from subjects of the AusDiab study and selected by means of propensity score to provide a cohort matched for kidney function (Cockcroft-Gault creatinine clearance). Results: Average hemoglobin level in kidney transplant recipients was (13.1 g/dL [131 g/L]; range, 9.0 to 18.0 g/dL), significantly less than in the general population (14.3 g/dL [143 g/L]; range, 9.7 to 20.0 g/dL). The prevalence of anemia (hemoglobin 12.0 g/dL [ 120 g/L] for females; 12.5 g/dL [ 125 g/L] for males) was almost 10-fold greater in kidney transplant recipients (30.8 ) versus the general population (3.4 ). Average hemoglobin level was lower in the kidney-transplant-recipient cohort at all levels of creatinine clearance. Considering both cohorts pooled, multivariate analysis showed that transplant status had the strongest association with anemia, followed by sex, creatinine clearance, and age. Conclusion: Posttransplantation anemia cannot be attributed solely to impaired kidney function.
Original languageEnglish
Pages (from-to)301 - 309
Number of pages9
JournalAmerican Journal of Kidney Diseases
Volume49
Issue number2
DOIs
Publication statusPublished - 2007

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