Androgenkonzentrationen und kardiovaskuläre Risiken bei der Frau

Hanna Kische, Robin Haring

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Low testosterone concentrations in men are associated with a higher cardiovascular risk factor burden. Also in women, cardiovascular risk increases after menopause. The aim of this work was to analyze potential associations between androgen concentrations in women and cardiovascular risk factors, including clinical correlates and sleep, metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), as well as subclinical and clinical cardiovascular disease (CVD) and mortality. Data from 2000 women of the population-based, longitudinal Study of Health in Pomerania (SHIP) and multivariable regression models were analyzed. Cardiovascular risk factors including obesity, hypertension, dyslipidemia, and poor sleep quality were associated with androgen concentration. Furthermore, cross-sectional and long-term analyses yielded inverse associations between sex hormone-binding globulin (SHBG) and MetS as well as T2DM. No independent, significant associations between androgen concentrations and incidence of CVD, CVD mortality, or all-cause mortality were detected. In this epidemiological study, clinical correlates of androgens in women and associations between androgens and sleep were identified. Associations between androgens, subclinical CVD, and mortality confirmed the relative impact of cofactors. SHBG might represent a potential biomarker for cardiovascular risk factors, especially among postmenopausal women.

Original languageEnglish
Pages (from-to)858-864
Number of pages7
JournalDer Gynaekologe
Volume49
Issue number11
DOIs
Publication statusPublished - Nov 2016
Externally publishedYes

Keywords

  • Cardiovascular diseases
  • Lipid metabolism
  • Metabolic syndrome
  • Sex Hormone-Binding Globulin
  • Sleep

Cite this