TY - JOUR
T1 - Androgen Receptor Repeat Length Polymorphism Associated with Male-to-Female Transsexualism
AU - Hare, Lauren May
AU - Bernard, Pascal
AU - Sanchez, Francisco J
AU - Baird, Paul N
AU - Vilain, Eric
AU - Kennedy, Trudy
AU - Harley, Vincent Russel
PY - 2009
Y1 - 2009
N2 - There is a likely genetic component to transsexualism, and genes involved in sex steroidogenesis are good candidates. We explored the specific hypothesis that male-to-female transsexualism is associated with gene variants responsible for undermasculinization and/or feminization. Specifically, we assessed the role of disease-associated repeat length polymorphisms in the androgen receptor (AR), estrogen receptor ? (ER?), and aromatase (CYP19) genes.
AB - There is a likely genetic component to transsexualism, and genes involved in sex steroidogenesis are good candidates. We explored the specific hypothesis that male-to-female transsexualism is associated with gene variants responsible for undermasculinization and/or feminization. Specifically, we assessed the role of disease-associated repeat length polymorphisms in the androgen receptor (AR), estrogen receptor ? (ER?), and aromatase (CYP19) genes.
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T4S-4TSSYJR-1&_user=542840&_coverDate=01%2F01%2F2009&_rdoc=1&_fmt=high&_orig=search&_sort=6
U2 - 10.1016/j.biopsych.2008.08.033
DO - 10.1016/j.biopsych.2008.08.033
M3 - Article
SN - 0006-3223
VL - 65
SP - 93
EP - 96
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 1
ER -