Androgen receptor expression and function in osteoclasts

Andrew Turner; Amanda Notini; W S Maria Chiu; Jason Hodge; Geoffrey Nicholson; Jeffrey Zajac; Rachel Davey

doi:10.2174/1874360900901010028

Androgen receptor expression and function in osteoclasts

Andrew Turner, Amanda Notini, W S Maria Chiu, Jason Hodge, Geoffrey Nicholson, Jeffrey Zajac, Rachel Davey

Research output: Contribution to journal › Article › Research › peer-review

Abstract

We assessed androgen receptor (AR) expression in osteoclasts in vitro and in situ. Rat multinucleated osteroclasts expressed detectable AR protein in situ and, AR mRNA was detected in mouse and human derived osteoclast-like cells in vitro. Dihydrotestosterone treatment did not affect human osteoclast-like cell formation or resorption in vitro.

Original language	English
Pages (from-to)	38 - 43
Number of pages	6
Journal	The Open Physiology Journal
Volume	1
DOIs	https://doi.org/10.2174/1874360900901010028
Publication status	Published - 2008
Externally published	Yes

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title = "Androgen receptor expression and function in osteoclasts",

abstract = "We assessed androgen receptor (AR) expression in osteoclasts in vitro and in situ. Rat multinucleated osteroclasts expressed detectable AR protein in situ and, AR mRNA was detected in mouse and human derived osteoclast-like cells in vitro. Dihydrotestosterone treatment did not affect human osteoclast-like cell formation or resorption in vitro.",

author = "Andrew Turner and Amanda Notini and Chiu, {W S Maria} and Jason Hodge and Geoffrey Nicholson and Jeffrey Zajac and Rachel Davey",

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AU - Turner, Andrew

AU - Notini, Amanda

AU - Chiu, W S Maria

AU - Hodge, Jason

AU - Nicholson, Geoffrey

AU - Zajac, Jeffrey

AU - Davey, Rachel

PY - 2008

Y1 - 2008

N2 - We assessed androgen receptor (AR) expression in osteoclasts in vitro and in situ. Rat multinucleated osteroclasts expressed detectable AR protein in situ and, AR mRNA was detected in mouse and human derived osteoclast-like cells in vitro. Dihydrotestosterone treatment did not affect human osteoclast-like cell formation or resorption in vitro.

AB - We assessed androgen receptor (AR) expression in osteoclasts in vitro and in situ. Rat multinucleated osteroclasts expressed detectable AR protein in situ and, AR mRNA was detected in mouse and human derived osteoclast-like cells in vitro. Dihydrotestosterone treatment did not affect human osteoclast-like cell formation or resorption in vitro.

UR - http://www.benthamscience.com/open/tophyj/articles/V001/28TOPHYJ.pdf

U2 - 10.2174/1874360900901010028

DO - 10.2174/1874360900901010028

M3 - Article

SN - 1874-3609

VL - 1

SP - 38

EP - 43

JO - The Open Physiology Journal

JF - The Open Physiology Journal

ER -

Androgen receptor expression and function in osteoclasts

Abstract

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