Ancient antimicrobial peptides kill antibiotic-resistant pathogens: Australian mammals provide new options

Jianghui Wang, Emily Wong, J Whitley, Jian Li, Jessica Stringer, Kirsty Short, Marilyn Renfree, K Belov, Benjamin Cocks

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Abstract

To overcome the increasing resistance of pathogens to existing antibiotics the 10?? 20 Initiative declared the urgent need for a global commitment to develop 10 new antimicrobial drugs by the year 2020. Naturally occurring animal antibiotics are an obvious place to start. The recently sequenced genomes of mammals that are divergent from human and mouse, including the tammar wallaby and the platypus, provide an opportunity to discover novel antimicrobials. Marsupials and monotremes are ideal potential sources of new antimicrobials because they give birth to underdeveloped immunologically na??ve young that develop outside the sterile confines of a uterus in harsh pathogen-laden environments. While their adaptive immune system develops innate immune factors produced either by the mother or by the young must play a key role in protecting the immune-compromised young. In this study we focus on the cathelicidins, a key family of antimicrobial peptide genes.
Original languageEnglish
Article numbere24030
Number of pages8
JournalPLoS ONE
Volume6
Issue number8
DOIs
Publication statusPublished - 2011

Cite this

Wang, Jianghui ; Wong, Emily ; Whitley, J ; Li, Jian ; Stringer, Jessica ; Short, Kirsty ; Renfree, Marilyn ; Belov, K ; Cocks, Benjamin. / Ancient antimicrobial peptides kill antibiotic-resistant pathogens: Australian mammals provide new options. In: PLoS ONE. 2011 ; Vol. 6, No. 8.
@article{6092b885e205468fb3a25a6426bc2de4,
title = "Ancient antimicrobial peptides kill antibiotic-resistant pathogens: Australian mammals provide new options",
abstract = "To overcome the increasing resistance of pathogens to existing antibiotics the 10?? 20 Initiative declared the urgent need for a global commitment to develop 10 new antimicrobial drugs by the year 2020. Naturally occurring animal antibiotics are an obvious place to start. The recently sequenced genomes of mammals that are divergent from human and mouse, including the tammar wallaby and the platypus, provide an opportunity to discover novel antimicrobials. Marsupials and monotremes are ideal potential sources of new antimicrobials because they give birth to underdeveloped immunologically na??ve young that develop outside the sterile confines of a uterus in harsh pathogen-laden environments. While their adaptive immune system develops innate immune factors produced either by the mother or by the young must play a key role in protecting the immune-compromised young. In this study we focus on the cathelicidins, a key family of antimicrobial peptide genes.",
author = "Jianghui Wang and Emily Wong and J Whitley and Jian Li and Jessica Stringer and Kirsty Short and Marilyn Renfree and K Belov and Benjamin Cocks",
year = "2011",
doi = "10.1371/journal.pone.0024030",
language = "English",
volume = "6",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",

}

Ancient antimicrobial peptides kill antibiotic-resistant pathogens: Australian mammals provide new options. / Wang, Jianghui; Wong, Emily; Whitley, J; Li, Jian; Stringer, Jessica; Short, Kirsty; Renfree, Marilyn; Belov, K; Cocks, Benjamin.

In: PLoS ONE, Vol. 6, No. 8, e24030, 2011.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Ancient antimicrobial peptides kill antibiotic-resistant pathogens: Australian mammals provide new options

AU - Wang, Jianghui

AU - Wong, Emily

AU - Whitley, J

AU - Li, Jian

AU - Stringer, Jessica

AU - Short, Kirsty

AU - Renfree, Marilyn

AU - Belov, K

AU - Cocks, Benjamin

PY - 2011

Y1 - 2011

N2 - To overcome the increasing resistance of pathogens to existing antibiotics the 10?? 20 Initiative declared the urgent need for a global commitment to develop 10 new antimicrobial drugs by the year 2020. Naturally occurring animal antibiotics are an obvious place to start. The recently sequenced genomes of mammals that are divergent from human and mouse, including the tammar wallaby and the platypus, provide an opportunity to discover novel antimicrobials. Marsupials and monotremes are ideal potential sources of new antimicrobials because they give birth to underdeveloped immunologically na??ve young that develop outside the sterile confines of a uterus in harsh pathogen-laden environments. While their adaptive immune system develops innate immune factors produced either by the mother or by the young must play a key role in protecting the immune-compromised young. In this study we focus on the cathelicidins, a key family of antimicrobial peptide genes.

AB - To overcome the increasing resistance of pathogens to existing antibiotics the 10?? 20 Initiative declared the urgent need for a global commitment to develop 10 new antimicrobial drugs by the year 2020. Naturally occurring animal antibiotics are an obvious place to start. The recently sequenced genomes of mammals that are divergent from human and mouse, including the tammar wallaby and the platypus, provide an opportunity to discover novel antimicrobials. Marsupials and monotremes are ideal potential sources of new antimicrobials because they give birth to underdeveloped immunologically na??ve young that develop outside the sterile confines of a uterus in harsh pathogen-laden environments. While their adaptive immune system develops innate immune factors produced either by the mother or by the young must play a key role in protecting the immune-compromised young. In this study we focus on the cathelicidins, a key family of antimicrobial peptide genes.

UR - http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0024030

U2 - 10.1371/journal.pone.0024030

DO - 10.1371/journal.pone.0024030

M3 - Article

VL - 6

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 8

M1 - e24030

ER -