Abstract
| Original language | English |
|---|---|
| Article number | e24030 |
| Number of pages | 8 |
| Journal | PLoS ONE |
| Volume | 6 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2011 |
Cite this
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Ancient antimicrobial peptides kill antibiotic-resistant pathogens: Australian mammals provide new options. / Wang, Jianghui; Wong, Emily; Whitley, J; Li, Jian; Stringer, Jessica; Short, Kirsty; Renfree, Marilyn; Belov, K; Cocks, Benjamin.
In: PLoS ONE, Vol. 6, No. 8, e24030, 2011.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Ancient antimicrobial peptides kill antibiotic-resistant pathogens: Australian mammals provide new options
AU - Wang, Jianghui
AU - Wong, Emily
AU - Whitley, J
AU - Li, Jian
AU - Stringer, Jessica
AU - Short, Kirsty
AU - Renfree, Marilyn
AU - Belov, K
AU - Cocks, Benjamin
PY - 2011
Y1 - 2011
N2 - To overcome the increasing resistance of pathogens to existing antibiotics the 10?? 20 Initiative declared the urgent need for a global commitment to develop 10 new antimicrobial drugs by the year 2020. Naturally occurring animal antibiotics are an obvious place to start. The recently sequenced genomes of mammals that are divergent from human and mouse, including the tammar wallaby and the platypus, provide an opportunity to discover novel antimicrobials. Marsupials and monotremes are ideal potential sources of new antimicrobials because they give birth to underdeveloped immunologically na??ve young that develop outside the sterile confines of a uterus in harsh pathogen-laden environments. While their adaptive immune system develops innate immune factors produced either by the mother or by the young must play a key role in protecting the immune-compromised young. In this study we focus on the cathelicidins, a key family of antimicrobial peptide genes.
AB - To overcome the increasing resistance of pathogens to existing antibiotics the 10?? 20 Initiative declared the urgent need for a global commitment to develop 10 new antimicrobial drugs by the year 2020. Naturally occurring animal antibiotics are an obvious place to start. The recently sequenced genomes of mammals that are divergent from human and mouse, including the tammar wallaby and the platypus, provide an opportunity to discover novel antimicrobials. Marsupials and monotremes are ideal potential sources of new antimicrobials because they give birth to underdeveloped immunologically na??ve young that develop outside the sterile confines of a uterus in harsh pathogen-laden environments. While their adaptive immune system develops innate immune factors produced either by the mother or by the young must play a key role in protecting the immune-compromised young. In this study we focus on the cathelicidins, a key family of antimicrobial peptide genes.
UR - http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0024030
U2 - 10.1371/journal.pone.0024030
DO - 10.1371/journal.pone.0024030
M3 - Article
VL - 6
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 8
M1 - e24030
ER -