Anchoring Group Effects of Surface Ligands on Magnetic Properties of Fe3O4 Nanoparticles: Towards high performance MRI contrast agents

Jianfeng Zeng, Lihong Jing, Yi Hou, Mingxia Jiao, Ruirui Qiao, Qiaojuan Jia, Chunyan Liu, Fang Fang, Hao Lei, Mingyuan Gao

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158 Citations (Scopus)


The effect of the anchoring group of surface ligands on the magnetic properties, especially relaxometric properties, of PEGylated Fe 3 O 4 nanoparticles is investigated. Systematic experimental results together with in-depth theoretical analysis reveal that the ligand binding affinity can largely vary the saturation magnetization, whereas conjugated anchoring groups can remarkably enhance the transverse relaxivity, which highlights a novel approach for achieving high-performance MRI contrast agents.

Original languageEnglish
Pages (from-to)2694-2698
Number of pages5
JournalAdvanced Materials
Issue number17
Publication statusPublished - 7 May 2014
Externally publishedYes


  • anchoring group
  • contrast enhancement effect
  • MRI
  • PEG ligand

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