Ancestral haplotypes: conserved population MHC haplotypes

Mariapia A. Degli-Esposti, Anne L. Leaver, Frank T. Christiansen, Campbell S. Witt, Lawrence J. Abraham, Roger L. Dawkins

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We describe here a number of Caucasoid MHC haplotypes that extend from HLA-B to DR and that have been conserved en bloc. These haplotypes and recombinants between any two of them account for 73% of unselected haplotypes in our Caucasoid population. The existence of ancestral haplotypes implies conservation of large chromosomal segments. Irrespective of the mechanisms involved in preservation of ancestral haplotypes, it is clear that these haplotypes carry several MHC genes, other than HLA, which may be relevant to antigen presentation, autoimmune responses, and transplantation rejection. In light of the existence of ancestral haplotypes, it is critical to evaluate MHC associations with disease and transplantation outcome in terms of associations with ancestral haplotypes rather than individual alleles.

Original languageEnglish
Pages (from-to)242-252
Number of pages11
JournalHuman Immunology
Issue number4
Publication statusPublished - 1 Jan 1992
Externally publishedYes

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