The quantitative structure-activity relationships (QSAR's) of 3 series of arylcyclohexylamines have been investigated using computational chemistry and multivariate statistics. Principal component analysis of the aromatic ring data set demonstrated some clustering of activity categories. Biological activity of the cyclohexane ring data set was correlated with molar refractivity. These findings may be useful for predicting the activity of novel neuroprotective agents.
|Number of pages||4|
|Publication status||Published - 1 Jan 1993|
- computational chemistry
- neuroprotective drugs
- phencyclidine analogues, quantitative structure-activity relationships