Analysis of structural order in amyloid fibrils

Tuomas P J Knowles, Jeffrey F Smith, Glyn Lee Devlin, Christopher M Dobson, Mark E Welland

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10 Citations (Scopus)

Abstract

We discuss the application of atomic force microscopy to characterize supra-molecular ordering in elongated protein aggregates such as amyloid fibrils. The measurements reveal that the one-dimensional defect density along these structures is comparable to that found in true three-dimensional macromolecular crystals. The high level of structural order has important implications for understanding the nature of the interactions responsible for protein aggregation, and sheds light on the involvement of amyloid fibrils in aberrant biological pathways
Original languageEnglish
Pages (from-to)1 - 5
Number of pages5
JournalNanotechnology
Volume18
Issue number4 (044031)
Publication statusPublished - 2007
Externally publishedYes

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