Analysis of serum interleukin(IL)-1α, IL-1β and IL-18 in patients with systemic sclerosis

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Abstract

Objectives: Systemic sclerosis (SSc) is an autoimmune disease characterised by fibrosis, vascular dysfunction and immune dysregulation. The pathogenesis of SSc remains poorly understood, although studies have indicated a role for the innate immune response. Methods: Here, we measured serum interleukin (IL)-1α, IL-1β and IL-18 levels in 105 SSc patients and 47 healthy controls (HC) and analysed them with respect to multiple clinical parameters. Results: Serum IL-18 concentrations were significantly higher in SSc patients than in HC, while no significant differences in concentrations of IL-1α and IL-1β were observed between SSc and HC. In both SSc and HC serum, IL-1α and IL-1β were positively correlated, while in SSc, both cytokines negatively correlated with IL-18. Serum IL-18 was significantly negatively correlated with both carbon monoxide transfer coefficient (KCO) and diffusing capacity of the lungs for carbon monoxide (DLCO). Serum IL-1β was positively correlated with the modified Rodnan skin score (mRSS), particularly in patients with limited subtype. DLCO, KCO and tricuspid regurgitation (TR) velocity were significantly higher in patients with high serum IL-1β. Serum IL-1α was significantly lower in SSc patients with low KCO and positively correlated with KCO. SSc patients with high serum IL-1α concentrations were more likely to have digital ulcers. Conclusions: Our data suggest that these IL-1 family cytokines may have different roles in the pathogenesis of SSc fibrotic complications.

Original languageEnglish
Article numbere1045
Number of pages11
JournalClinical and Translational Immunology
Volume8
Issue number4
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • biomarker
  • IL-18
  • IL-1β
  • inflammation
  • interleukin (IL)-1α
  • scleroderma

Cite this

@article{224a008c1abc480b91b0e5b8671cb0a1,
title = "Analysis of serum interleukin(IL)-1α, IL-1β and IL-18 in patients with systemic sclerosis",
abstract = "Objectives: Systemic sclerosis (SSc) is an autoimmune disease characterised by fibrosis, vascular dysfunction and immune dysregulation. The pathogenesis of SSc remains poorly understood, although studies have indicated a role for the innate immune response. Methods: Here, we measured serum interleukin (IL)-1α, IL-1β and IL-18 levels in 105 SSc patients and 47 healthy controls (HC) and analysed them with respect to multiple clinical parameters. Results: Serum IL-18 concentrations were significantly higher in SSc patients than in HC, while no significant differences in concentrations of IL-1α and IL-1β were observed between SSc and HC. In both SSc and HC serum, IL-1α and IL-1β were positively correlated, while in SSc, both cytokines negatively correlated with IL-18. Serum IL-18 was significantly negatively correlated with both carbon monoxide transfer coefficient (KCO) and diffusing capacity of the lungs for carbon monoxide (DLCO). Serum IL-1β was positively correlated with the modified Rodnan skin score (mRSS), particularly in patients with limited subtype. DLCO, KCO and tricuspid regurgitation (TR) velocity were significantly higher in patients with high serum IL-1β. Serum IL-1α was significantly lower in SSc patients with low KCO and positively correlated with KCO. SSc patients with high serum IL-1α concentrations were more likely to have digital ulcers. Conclusions: Our data suggest that these IL-1 family cytokines may have different roles in the pathogenesis of SSc fibrotic complications.",
keywords = "biomarker, IL-18, IL-1β, inflammation, interleukin (IL)-1α, scleroderma",
author = "Emily Lin and Vincent, {Fabien B} and Joanne Sahhar and Gene-Siew Ngian and Rangi Kandane-Rathnayake and Rachel Mende and Morand, {Eric F.} and Tali Lang and James Harris",
year = "2019",
month = "1",
day = "1",
doi = "10.1002/cti2.1045",
language = "English",
volume = "8",
journal = "Clinical and Translational Immunology",
issn = "2050-0068",
publisher = "Nature Publishing Group",
number = "4",

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TY - JOUR

T1 - Analysis of serum interleukin(IL)-1α, IL-1β and IL-18 in patients with systemic sclerosis

AU - Lin, Emily

AU - Vincent, Fabien B

AU - Sahhar, Joanne

AU - Ngian, Gene-Siew

AU - Kandane-Rathnayake, Rangi

AU - Mende, Rachel

AU - Morand, Eric F.

AU - Lang, Tali

AU - Harris, James

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objectives: Systemic sclerosis (SSc) is an autoimmune disease characterised by fibrosis, vascular dysfunction and immune dysregulation. The pathogenesis of SSc remains poorly understood, although studies have indicated a role for the innate immune response. Methods: Here, we measured serum interleukin (IL)-1α, IL-1β and IL-18 levels in 105 SSc patients and 47 healthy controls (HC) and analysed them with respect to multiple clinical parameters. Results: Serum IL-18 concentrations were significantly higher in SSc patients than in HC, while no significant differences in concentrations of IL-1α and IL-1β were observed between SSc and HC. In both SSc and HC serum, IL-1α and IL-1β were positively correlated, while in SSc, both cytokines negatively correlated with IL-18. Serum IL-18 was significantly negatively correlated with both carbon monoxide transfer coefficient (KCO) and diffusing capacity of the lungs for carbon monoxide (DLCO). Serum IL-1β was positively correlated with the modified Rodnan skin score (mRSS), particularly in patients with limited subtype. DLCO, KCO and tricuspid regurgitation (TR) velocity were significantly higher in patients with high serum IL-1β. Serum IL-1α was significantly lower in SSc patients with low KCO and positively correlated with KCO. SSc patients with high serum IL-1α concentrations were more likely to have digital ulcers. Conclusions: Our data suggest that these IL-1 family cytokines may have different roles in the pathogenesis of SSc fibrotic complications.

AB - Objectives: Systemic sclerosis (SSc) is an autoimmune disease characterised by fibrosis, vascular dysfunction and immune dysregulation. The pathogenesis of SSc remains poorly understood, although studies have indicated a role for the innate immune response. Methods: Here, we measured serum interleukin (IL)-1α, IL-1β and IL-18 levels in 105 SSc patients and 47 healthy controls (HC) and analysed them with respect to multiple clinical parameters. Results: Serum IL-18 concentrations were significantly higher in SSc patients than in HC, while no significant differences in concentrations of IL-1α and IL-1β were observed between SSc and HC. In both SSc and HC serum, IL-1α and IL-1β were positively correlated, while in SSc, both cytokines negatively correlated with IL-18. Serum IL-18 was significantly negatively correlated with both carbon monoxide transfer coefficient (KCO) and diffusing capacity of the lungs for carbon monoxide (DLCO). Serum IL-1β was positively correlated with the modified Rodnan skin score (mRSS), particularly in patients with limited subtype. DLCO, KCO and tricuspid regurgitation (TR) velocity were significantly higher in patients with high serum IL-1β. Serum IL-1α was significantly lower in SSc patients with low KCO and positively correlated with KCO. SSc patients with high serum IL-1α concentrations were more likely to have digital ulcers. Conclusions: Our data suggest that these IL-1 family cytokines may have different roles in the pathogenesis of SSc fibrotic complications.

KW - biomarker

KW - IL-18

KW - IL-1β

KW - inflammation

KW - interleukin (IL)-1α

KW - scleroderma

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U2 - 10.1002/cti2.1045

DO - 10.1002/cti2.1045

M3 - Article

VL - 8

JO - Clinical and Translational Immunology

JF - Clinical and Translational Immunology

SN - 2050-0068

IS - 4

M1 - e1045

ER -