Analysis of an optimal control problem for the tridomain model in cardiac electrophysiology

Bedr'Eddine Ainseba, Mostafa Bendahmane, Ricardo Ruiz-Baier

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7 Citations (Scopus)

Abstract

In the present paper, an optimal control problem constrained by the tridomain equations in electrocardiology is investigated. The state equations consisting in a coupled reaction-diffusion system modeling the propagation of the intracellular and extracellular electrical potentials, and ionic currents, are extended to further consider the effect of an external bathing medium. The existence and uniqueness of solution for the tridomain problem and the related control problem is assessed, and the primal and dual problems are discretized using a finite volume method which is proved to converge to the corresponding weak solution. In order to illustrate the control of the electrophysiological dynamics, we present some preliminary numerical experiments using an efficient implementation of the proposed scheme.

Original languageEnglish
Pages (from-to)231-247
Number of pages17
JournalJournal of Mathematical Analysis and Applications
Volume388
Issue number1
DOIs
Publication statusPublished - 1 Apr 2012
Externally publishedYes

Keywords

  • Cardiac electrophysiology
  • Convergence
  • Finite volume approximation
  • Optimal control
  • Tridomain model

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