Analysis of ADC model robustness in diffusion-weighted MRI

Syeda Warda Taqdees, Amanda Ng, David K. Wright, Mary Tolcos, Leigh A. Johnston

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review


A variety of parametric models based on the Apparent Diffusion Coefficient (ADC) have been proposed to describe signal decay in the interpretation of diffusion weighted Magnetic Resonance Imaging data. In this work, we investigate the robustness of several of these models, including the exponential model, bi-exponential model and the recently proposed gamma distribution model, using a Crámer-Rao lower bound analysis. It is demonstrated that the parameters of all models are susceptible to significant estimation errors at the current gradient strengths of clinical scanners. To complement the theoretical analysis, the robustness of the models is compared through application to experimental ovine optic nerve and rat brain MRI data. Our results indicate that gamma distribution model fits experimental data better than the commonly employed bi-exponential model.

Original languageEnglish
Title of host publication2017 IEEE 14th International Symposium on Biomedical Imaging (ISBI 2017)
Place of PublicationPiscataway NJ USA
PublisherIEEE, Institute of Electrical and Electronics Engineers
Number of pages4
ISBN (Electronic)9781509011711, 9781509011728
ISBN (Print)9781509011735
Publication statusPublished - 15 Jun 2017
EventIEEE International Symposium on Biomedical Imaging (ISBI) 2017 - Melbourne Convention and Exhibition Centre, Melbourne, Australia
Duration: 18 Apr 201721 Apr 2017
Conference number: 14th


ConferenceIEEE International Symposium on Biomedical Imaging (ISBI) 2017
Abbreviated titleISBI 2017
OtherISBI is a joint initiative from the IEEE Signal Processing Society (SPS) and the IEEE Engineering in Medicine and Biology Society (EMBS). The 2017 meeting will include tutorials, and a scientific program composed of plenary talks, invited special sessions, challenges, as well as oral and poster presentations of peer-reviewed papers.
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  • Apparent diffusion coefficient
  • Crámer-Rao lower bound analysis
  • Diffusion weighted MRI
  • Gamma distribution
  • Restricted diffusion

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