Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients

Leif Törkvist; Jonas Halfvarson; Rick T.H. Ong; Mikael Lördal; Urban Sjöqvist; Francesca Bresso; Jan Björk; Ragnar Befrits; Robert Löfberg; Johannes Blom; Marie Carlson; Leonid Padyukov; Mauro D'Amato; Mark Seielstad; Sven Pettersson

doi:10.1002/ibd.21105

Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients

Leif Törkvist, Jonas Halfvarson, Rick T.H. Ong, Mikael Lördal, Urban Sjöqvist, Francesca Bresso, Jan Björk, Ragnar Befrits, Robert Löfberg, Johannes Blom, Marie Carlson, Leonid Padyukov, Mauro D'Amato, Mark Seielstad, Sven Pettersson

Research output: Contribution to journal › Letter › Other › peer-review

16 Citations (Scopus)

Abstract

Whether Crohn's disease (CD) and ulcerative colitis (UC) represent distinct disorders or comprise a continuum is a key question in inflammatory bowel disease (IBD). Recently, genome-wide association studies (GWAS) have identified several susceptibility loci, particularly for CD. This progress has enabled attempts to define the molecular similarity of IBD subtypes by specifically testing CD loci in UC. Here we extend this approach by genotyping a Swedish sample of 736 CD patients (age 49.4 ± 15.9 SD, 50.9% males), 935 UC patients (age 51.6 ± 13.1 SD, 54.2% males) and 1460 common controls (age 49.8 ± 15.6 SD, 35.6% males) for 39 of 40 loci nominally associated with CD in a recent GWAS meta-analysis.

Original language	English
Pages (from-to)	907-909
Number of pages	3
Journal	Inflammatory Bowel Diseases
Volume	16
Issue number	6
DOIs	https://doi.org/10.1002/ibd.21105
Publication status	Published - 31 May 2010
Externally published	Yes

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Törkvist, L., Halfvarson, J., Ong, R. T. H., Lördal, M., Sjöqvist, U., Bresso, F., Björk, J., Befrits, R., Löfberg, R., Blom, J., Carlson, M., Padyukov, L., D'Amato, M., Seielstad, M., & Pettersson, S. (2010). Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients. Inflammatory Bowel Diseases, 16(6), 907-909. https://doi.org/10.1002/ibd.21105

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title = "Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients",

abstract = "Whether Crohn's disease (CD) and ulcerative colitis (UC) represent distinct disorders or comprise a continuum is a key question in inflammatory bowel disease (IBD). Recently, genome-wide association studies (GWAS) have identified several susceptibility loci, particularly for CD. This progress has enabled attempts to define the molecular similarity of IBD subtypes by specifically testing CD loci in UC. Here we extend this approach by genotyping a Swedish sample of 736 CD patients (age 49.4 ± 15.9 SD, 50.9% males), 935 UC patients (age 51.6 ± 13.1 SD, 54.2% males) and 1460 common controls (age 49.8 ± 15.6 SD, 35.6% males) for 39 of 40 loci nominally associated with CD in a recent GWAS meta-analysis.",

author = "Leif T{\"o}rkvist and Jonas Halfvarson and Ong, {Rick T.H.} and Mikael L{\"o}rdal and Urban Sj{\"o}qvist and Francesca Bresso and Jan Bj{\"o}rk and Ragnar Befrits and Robert L{\"o}fberg and Johannes Blom and Marie Carlson and Leonid Padyukov and Mauro D'Amato and Mark Seielstad and Sven Pettersson",

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Törkvist, L, Halfvarson, J, Ong, RTH, Lördal, M, Sjöqvist, U, Bresso, F, Björk, J, Befrits, R, Löfberg, R, Blom, J, Carlson, M, Padyukov, L, D'Amato, M, Seielstad, M & Pettersson, S 2010, 'Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients', Inflammatory Bowel Diseases, vol. 16, no. 6, pp. 907-909. https://doi.org/10.1002/ibd.21105

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T1 - Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients

AU - Törkvist, Leif

AU - Halfvarson, Jonas

AU - Ong, Rick T.H.

AU - Lördal, Mikael

AU - Sjöqvist, Urban

AU - Bresso, Francesca

AU - Björk, Jan

AU - Befrits, Ragnar

AU - Löfberg, Robert

AU - Blom, Johannes

AU - Carlson, Marie

AU - Padyukov, Leonid

AU - D'Amato, Mauro

AU - Seielstad, Mark

AU - Pettersson, Sven

PY - 2010/5/31

Y1 - 2010/5/31

N2 - Whether Crohn's disease (CD) and ulcerative colitis (UC) represent distinct disorders or comprise a continuum is a key question in inflammatory bowel disease (IBD). Recently, genome-wide association studies (GWAS) have identified several susceptibility loci, particularly for CD. This progress has enabled attempts to define the molecular similarity of IBD subtypes by specifically testing CD loci in UC. Here we extend this approach by genotyping a Swedish sample of 736 CD patients (age 49.4 ± 15.9 SD, 50.9% males), 935 UC patients (age 51.6 ± 13.1 SD, 54.2% males) and 1460 common controls (age 49.8 ± 15.6 SD, 35.6% males) for 39 of 40 loci nominally associated with CD in a recent GWAS meta-analysis.

AB - Whether Crohn's disease (CD) and ulcerative colitis (UC) represent distinct disorders or comprise a continuum is a key question in inflammatory bowel disease (IBD). Recently, genome-wide association studies (GWAS) have identified several susceptibility loci, particularly for CD. This progress has enabled attempts to define the molecular similarity of IBD subtypes by specifically testing CD loci in UC. Here we extend this approach by genotyping a Swedish sample of 736 CD patients (age 49.4 ± 15.9 SD, 50.9% males), 935 UC patients (age 51.6 ± 13.1 SD, 54.2% males) and 1460 common controls (age 49.8 ± 15.6 SD, 35.6% males) for 39 of 40 loci nominally associated with CD in a recent GWAS meta-analysis.

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DO - 10.1002/ibd.21105

M3 - Letter

C2 - 19760754

AN - SCOPUS:77952708864

SN - 1078-0998

VL - 16

SP - 907

EP - 909

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

IS - 6

ER -

Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients

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