Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients

Leif Törkvist, Jonas Halfvarson, Rick T.H. Ong, Mikael Lördal, Urban Sjöqvist, Francesca Bresso, Jan Björk, Ragnar Befrits, Robert Löfberg, Johannes Blom, Marie Carlson, Leonid Padyukov, Mauro D'Amato, Mark Seielstad, Sven Pettersson

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14 Citations (Scopus)

Abstract

Whether Crohn's disease (CD) and ulcerative colitis (UC) represent distinct disorders or comprise a continuum is a key question in inflammatory bowel disease (IBD). Recently, genome-wide association studies (GWAS) have identified several susceptibility loci, particularly for CD. This progress has enabled attempts to define the molecular similarity of IBD subtypes by specifically testing CD loci in UC. Here we extend this approach by genotyping a Swedish sample of 736 CD patients (age 49.4 ± 15.9 SD, 50.9% males), 935 UC patients (age 51.6 ± 13.1 SD, 54.2% males) and 1460 common controls (age 49.8 ± 15.6 SD, 35.6% males) for 39 of 40 loci nominally associated with CD in a recent GWAS meta-analysis.
Original languageEnglish
Pages (from-to)907-909
Number of pages3
JournalInflammatory Bowel Diseases
Volume16
Issue number6
DOIs
Publication statusPublished - 31 May 2010
Externally publishedYes

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