Analysis of 1 year virtual histology changes in coronary plaque located behind the struts of the everolimus eluting bioresorbable vascular scaffold

Salvatore Brugaletta, Josep Gomez-Lara, Hector M Garcia-Garcia, Jung Ho Heo, Vasim Farooq, Robert-Jan van Geuns, Bernard Chevalier, Stephan Windecker, Dougal McClean, Leif Thuesen, Robert Whitbourn, Ian Meredith, Cecile Dorange, Susan Veldhof, Richard Rapoza, John A Ormiston, Patrick W Serruys

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Serial intravascular ultrasound virtual histology (IVUS-VH) after implantation of metallic stents has been unable to show any changes in the composition of the scaffolded plaque overtime. The everolimus- eluting ABSORB scaffold potentially allows for the formation of new fibrotic tissue on the scaffolded coronary plaque during bioresorption. We examined the 12 month IVUS-VH changes in composition of the plaque behind the struts (PBS) following the implantation of the ABSORB scaffold. Using IVUS-VH and dedicated software, the composition of the PBS was analyzed in all patients from the ABSORB Cohort B2 trial, who were imaged with a commercially available IVUS-VH console (s5i system, Volcano Corporation, Rancho Cordova, CA, USA), immediately post- ABSORB implantation and at 12 month follow-up. Paired IVUS-VH data, recorded with s5i system, were available in 17 patients (18 lesions). The analysis demonstrated an increase in mean PBS area (2.39 ± 1.85 mm2 vs. 2.76 ± 1.79 mm2, P = 0.078) and a reduction in the mean lumen area (6.37 ± 0.90 mm2 vs. 5.98 ± 0.97 mm2, P = 0.006). Conversely, a significant decrease of 16 and 30% in necrotic core (NC) and dense calcium (DC) content, respectively, were evident (median % NC from 43.24 to 36.06%, P = 0.016; median % DC from 20.28 to 11.36%, P = 0.002). Serial IVUS-VH analyses of plaque located behind the ABSORB struts at 12-month demonstrated an increase in plaque area with a decrease in its NC and DC content. Larger studies are required to investigate the clinical impact of these findings.

Original languageEnglish
Pages (from-to)1307-1314
Number of pages8
JournalInternational Journal of Cardiovascular Imaging
Issue number6
Publication statusPublished - Aug 2012
Externally publishedYes


  • Bioresorbable vascular scaffold
  • Coronary plaque
  • Everolimus
  • Necrotic core

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