TY - JOUR
T1 - Analgesic and anti-inflammatory activities of flower extracts of Punica granatum Linn. (Punicaceae)
AU - Sarker, Mithun
AU - Das, Sreedam Chandra
AU - Saha, Sajal Kumar
AU - Al Mahmud, Zobaer
AU - Bachar, Sitesh Chandra
PY - 2012/4
Y1 - 2012/4
N2 - Punica granatum has been used for centuries to confer health benefits in a number of inflammatory diseases. Based on its usage in Ayurvedic and Unani medicine, dietary supplements containing pomegranate extract are becoming popular for the treatment and prevention of arthritis and other inflammatory diseases. Pet-ether, dichloromethane and methanol fractions of flower part were chosen for pharmacological screening and analgesic and anti-inflammatory activities in animal model. The anti-inflammatory activity was assessed using the carrageenan-inducedrat paw edema model. The analgesic effect was measured in mice using the acetic acid-induced writhing test. In the acetic acid-induced writhing test in mice, pet-ether, dichloromethane and methanol fractions at 200 mg/kg doses level showed 75.77% (p<0.001), 68.56% (p<0.001), 54.64% (p<0.001) inhibition of writhing, respectively. In rat paw edema model induced by carrageenan, pet-ether, dichloromethane and methanol fractions were found to reducesignificantly (p<0.001) the formation of edema at the 100 mg/kg dose level and showed 26.92% (p<0.001), 27.97%(p<0.001), 21.85%(p<0.001) inhibition respectively of edema volume at the end of 4 h. Punica granatum possesses evident analgesic and anti-inflammatory activities. The results signify the traditional uses of Punica granatum for inflammation and pain.
AB - Punica granatum has been used for centuries to confer health benefits in a number of inflammatory diseases. Based on its usage in Ayurvedic and Unani medicine, dietary supplements containing pomegranate extract are becoming popular for the treatment and prevention of arthritis and other inflammatory diseases. Pet-ether, dichloromethane and methanol fractions of flower part were chosen for pharmacological screening and analgesic and anti-inflammatory activities in animal model. The anti-inflammatory activity was assessed using the carrageenan-inducedrat paw edema model. The analgesic effect was measured in mice using the acetic acid-induced writhing test. In the acetic acid-induced writhing test in mice, pet-ether, dichloromethane and methanol fractions at 200 mg/kg doses level showed 75.77% (p<0.001), 68.56% (p<0.001), 54.64% (p<0.001) inhibition of writhing, respectively. In rat paw edema model induced by carrageenan, pet-ether, dichloromethane and methanol fractions were found to reducesignificantly (p<0.001) the formation of edema at the 100 mg/kg dose level and showed 26.92% (p<0.001), 27.97%(p<0.001), 21.85%(p<0.001) inhibition respectively of edema volume at the end of 4 h. Punica granatum possesses evident analgesic and anti-inflammatory activities. The results signify the traditional uses of Punica granatum for inflammation and pain.
KW - Analgesic
KW - Anti-inflammatory
KW - Carrageenan
KW - Punica granatum
KW - Punicaceae
UR - http://www.scopus.com/inward/record.url?scp=84871776371&partnerID=8YFLogxK
U2 - 10.7324/JAPS.2012.2408
DO - 10.7324/JAPS.2012.2408
M3 - Article
AN - SCOPUS:84871776371
SN - 2231-3354
VL - 2
SP - 133
EP - 136
JO - Journal of Applied Pharmaceutical Science
JF - Journal of Applied Pharmaceutical Science
IS - 4
ER -