Anaemia in Kidney Transplant Recipients in the First Year

Arushi Kansal, John Kanellis, Andy K.H. Lim

Research output: Contribution to journalMeeting Abstract

Abstract

Aim
To determine the prevalence and risk factors for anaemia in kidney transplant recipients in the first 12 months after transplantation.
Background
Anaemia outside the immediate post-operative period appears common. Moderate-severe anaemia may affect quality of life and need for blood transfusions and consequent immunological sensitization. Understanding the risk factors for anaemia may help with its prevention or management.
Methods
A cross-sectional study was conducted at Monash Health at 6 and 12 months for adult kidney transplants performed between Jan 2011 and Dec 2015. The main binary outcome was moderate-severe anaemia defined by WHO criteria. Patients with allograft failure, deceased or lack sufficient clinical data were excluded.
Results
The analysis included 336 transplant recipients, with a mean age of 51 ± 13 years (65% male), 29% live donation and 7% kidney-pancreas transplants. The prevalence of mild anaemia was 28% and 23% at 6 and 12 months, respectively. The prevalence of moderate-severe anaemia was 18% and 10% at 6 and 12 months, respectively. Use of erythropoietin declined from 17% at 6 months to 8% at 12 months. Ferritin and cobalamin levels were lower at 12 months compared to 6 months. In multivariate logistic regression analysis, the risk factors for moderate-severe anaemia at 6 months were female gender, allograft function, intravenous immunoglobulin exposure, transferrin saturation and proteinuria. In the 12 months analysis, the risk factors were allograft function, recent infection, cobalamin levels, serum ferritin and proteinuria.
Conclusions
The frequency and severity of anaemia is less at 12 months compared to 6 months. The risk factors for moderate-severe anaemia are slightly different at 6 and 12 months but allograft function and proteinuria are prevailing factors.
Original languageEnglish
Pages (from-to)41
Number of pages1
JournalNephrology
Volume22
Issue numberS3
DOIs
Publication statusPublished - Sep 2017
EventAnnual Scientific Meeting of the Australian-and-New-Zealand-Society-of-Nephrology 2017 - Darwin Convention Centre, Darwin, Australia
Duration: 4 Sep 20176 Sep 2017
Conference number: 53rd
https://onlinelibrary.wiley.com/toc/14401797/2017/22/S3 (Nephrology Vol 22, Issue S3)

Cite this