TY - JOUR
T1 - An Update on the Measurement of Motor Cerebellar Dysfunction in Multiple Sclerosis
AU - Kenyon, Katherine Hope
AU - Boonstra, Frederique
AU - Noffs, Gustavo
AU - Butzkueven, Helmut
AU - Vogel, Adam P.
AU - Kolbe, Scott
AU - van der Walt, Anneke
N1 - Funding Information:
Anneke van der Walt served on advisory boards and receives unrestricted research grants from Novartis, Biogen, Merck, and Roche. She has received speaker’s honoraria and travel support from Novartis, Roche, and Merck. She receives grant support from the National Health and Medical Research Council of Australia and MS Research Australia. Adam Vogel is Chief Science Officer of Redenlab Inc. Gustavo Noffs works in scientific development for Redenlab Inc. Scott Kolbe receives grant income from MS Research Australia and has received honoraria from Novartis, Biogen, and Merck. Helmut Butzkueven’s institution receives compensation for serving on scientific advisory boards and speaker bureaus for Biogen, Novartis, Roche, Merck, and UCB, steering committee duties for trials conducted by Biogen, Merck, Roche, and Novartis and his institution receives research support from Merck, Roche, Novartis, ALexion, and Biogen.
Publisher Copyright:
© 2022, The Author(s).
PY - 2023/8
Y1 - 2023/8
N2 - Multiple sclerosis (MS) is a progressive disease that often affects the cerebellum. It is characterised by demyelination, inflammation, and neurodegeneration within the central nervous system. Damage to the cerebellum in MS is associated with increased disability and decreased quality of life. Symptoms include gait and balance problems, motor speech disorder, upper limb dysfunction, and oculomotor difficulties. Monitoring symptoms is crucial for effective management of MS. A combination of clinical, neuroimaging, and task-based measures is generally used to diagnose and monitor MS. This paper reviews the present and new tools used by clinicians and researchers to assess cerebellar impairment in people with MS (pwMS). It also describes recent advances in digital and home-based monitoring for people with MS.
AB - Multiple sclerosis (MS) is a progressive disease that often affects the cerebellum. It is characterised by demyelination, inflammation, and neurodegeneration within the central nervous system. Damage to the cerebellum in MS is associated with increased disability and decreased quality of life. Symptoms include gait and balance problems, motor speech disorder, upper limb dysfunction, and oculomotor difficulties. Monitoring symptoms is crucial for effective management of MS. A combination of clinical, neuroimaging, and task-based measures is generally used to diagnose and monitor MS. This paper reviews the present and new tools used by clinicians and researchers to assess cerebellar impairment in people with MS (pwMS). It also describes recent advances in digital and home-based monitoring for people with MS.
KW - Acoustic speech analysis
KW - Cerebellum
KW - Home-based monitoring
KW - Multiple sclerosis
KW - Neuroimaging
UR - http://www.scopus.com/inward/record.url?scp=85132925125&partnerID=8YFLogxK
U2 - 10.1007/s12311-022-01435-y
DO - 10.1007/s12311-022-01435-y
M3 - Review Article
C2 - 35761144
AN - SCOPUS:85132925125
SN - 1473-4222
VL - 22
SP - 761
EP - 775
JO - The Cerebellum
JF - The Cerebellum
IS - 4
ER -