An unusual presentation of herpes simplex virus encephalitis

Ray Boyapati, George Papadopoulos, James Olver, Michael Geluk, Paul D.R. Johnson

Research output: Contribution to journalArticleOtherpeer-review

6 Citations (Scopus)

Abstract

We present a case of a 65-year-old man with an acute alteration in mental state that was initially diagnosed as a functional psychiatric condition. After extensive workup, herpes simplex virus type 1 (HSV-1) was detected in the patient's cerebrospinal fluid (CSF) by polymerase chain reaction (PCR), and he responded rapidly to treatment with acyclovir. The case illustrates the importance of actively excluding organic causes in such patients, the need to have a low threshold of suspicion for HSV encephalitis, and the central role of CSF PCR testing for the diagnosis of HSV encephalitis, even in the absence of CSF biochemical abnormalities.

Original languageEnglish
Article number241710
Number of pages4
JournalCase Reports in Medicine
Volume2012
DOIs
Publication statusPublished - 1 Jan 2012
Externally publishedYes

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