An unusual phosphatidylinositol turnover pathway in noradrenaline-perfused rat hearts

Elizabeth A. Woodcock; A. Ian Smith; Catherine A. Wallace; L. Barbara Schmauk White

doi:10.1111/j.1440-1681.1988.tb01067.x

An unusual phosphatidylinositol turnover pathway in noradrenaline-perfused rat hearts

Elizabeth A. Woodcock, A. Ian Smith, Catherine A. Wallace, L. Barbara Schmauk White

Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Abstract

1. The phosphatidylinositol turnover pathway has been studied in noradrenaline‐perfused rat hearts using anion‐exchange high performance liquid chromatography. 2. The active calcium‐releasing compound inositol‐(1,4,5)trisphosphate was detected together with its degradation products inositol‐(1,4)bisphosphate and inositol monophosphate. All these products increased in response to noradrenaline stimulation. 3. At noradrenaline perfusion times from 5 s to 20 min there was no appearance of inositol‐(1,3,4,5)tetrakisphosphate or its degradation products: inositol‐(1,3,4)trisphosphate or inositol‐(1,3) and (3,4)bisphosphates. 4. These data suggest the absence of the inositol‐(1,4,5)trisphosphate phosphorylation/dephosphorylation pathway in heart.

Original language	English
Pages (from-to)	251-255
Number of pages	5
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	15
Issue number	4
DOIs	https://doi.org/10.1111/j.1440-1681.1988.tb01067.x
Publication status	Published - 1 Jan 1988

Keywords

calcium‐releasing compound
dephosphorylation pathway
noradrenaline perfusion
phosphatidylinositol turnover.

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10.1111/j.1440-1681.1988.tb01067.x

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abstract = "1. The phosphatidylinositol turnover pathway has been studied in noradrenaline‐perfused rat hearts using anion‐exchange high performance liquid chromatography. 2. The active calcium‐releasing compound inositol‐(1,4,5)trisphosphate was detected together with its degradation products inositol‐(1,4)bisphosphate and inositol monophosphate. All these products increased in response to noradrenaline stimulation. 3. At noradrenaline perfusion times from 5 s to 20 min there was no appearance of inositol‐(1,3,4,5)tetrakisphosphate or its degradation products: inositol‐(1,3,4)trisphosphate or inositol‐(1,3) and (3,4)bisphosphates. 4. These data suggest the absence of the inositol‐(1,4,5)trisphosphate phosphorylation/dephosphorylation pathway in heart.",

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N2 - 1. The phosphatidylinositol turnover pathway has been studied in noradrenaline‐perfused rat hearts using anion‐exchange high performance liquid chromatography. 2. The active calcium‐releasing compound inositol‐(1,4,5)trisphosphate was detected together with its degradation products inositol‐(1,4)bisphosphate and inositol monophosphate. All these products increased in response to noradrenaline stimulation. 3. At noradrenaline perfusion times from 5 s to 20 min there was no appearance of inositol‐(1,3,4,5)tetrakisphosphate or its degradation products: inositol‐(1,3,4)trisphosphate or inositol‐(1,3) and (3,4)bisphosphates. 4. These data suggest the absence of the inositol‐(1,4,5)trisphosphate phosphorylation/dephosphorylation pathway in heart.

AB - 1. The phosphatidylinositol turnover pathway has been studied in noradrenaline‐perfused rat hearts using anion‐exchange high performance liquid chromatography. 2. The active calcium‐releasing compound inositol‐(1,4,5)trisphosphate was detected together with its degradation products inositol‐(1,4)bisphosphate and inositol monophosphate. All these products increased in response to noradrenaline stimulation. 3. At noradrenaline perfusion times from 5 s to 20 min there was no appearance of inositol‐(1,3,4,5)tetrakisphosphate or its degradation products: inositol‐(1,3,4)trisphosphate or inositol‐(1,3) and (3,4)bisphosphates. 4. These data suggest the absence of the inositol‐(1,4,5)trisphosphate phosphorylation/dephosphorylation pathway in heart.

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KW - dephosphorylation pathway

KW - noradrenaline perfusion

KW - phosphatidylinositol turnover.

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ER -

An unusual phosphatidylinositol turnover pathway in noradrenaline-perfused rat hearts

Abstract

Keywords

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