An unusual phosphatidylinositol turnover pathway in noradrenaline-perfused rat hearts

Elizabeth A. Woodcock, A. Ian Smith, Catherine A. Wallace, L. Barbara Schmauk White

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3 Citations (Scopus)


1. The phosphatidylinositol turnover pathway has been studied in noradrenaline‐perfused rat hearts using anion‐exchange high performance liquid chromatography. 2. The active calcium‐releasing compound inositol‐(1,4,5)trisphosphate was detected together with its degradation products inositol‐(1,4)bisphosphate and inositol monophosphate. All these products increased in response to noradrenaline stimulation. 3. At noradrenaline perfusion times from 5 s to 20 min there was no appearance of inositol‐(1,3,4,5)tetrakisphosphate or its degradation products: inositol‐(1,3,4)trisphosphate or inositol‐(1,3) and (3,4)bisphosphates. 4. These data suggest the absence of the inositol‐(1,4,5)trisphosphate phosphorylation/dephosphorylation pathway in heart.

Original languageEnglish
Pages (from-to)251-255
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Issue number4
Publication statusPublished - 1 Jan 1988


  • calcium‐releasing compound
  • dephosphorylation pathway
  • noradrenaline perfusion
  • phosphatidylinositol turnover.

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