Projects per year
Abstract
The development of acute kidney injury (AKI) is both a significant and independent prognostic factor of mortality in patients with sepsis, but its pathophysiology remains unclear. Herein, we describe an ovine model of sepsis evoked by the administration of live Escherichia coli in which there is hypotension, peripheral vasodilatation with a large increase in cardiac output; a similar hyperdynamic state to that commonly reported in humans. Interestingly, in this sheep model of sepsis, despite an increase in global kidney blood flow, there is a progressive reduction in renal function. Although renal hyperperfusion develops, renal tissue hypoxia due to redistribution of intrarenal blood flow may contribute to the pathogenesis of septic AKI. We have, therefore, developed a novel methodology to chronically implant combination probes to monitor intrarenal tissue perfusion and oxygen tension during the development of septic AKI in conscious sheep with hyperdynamic sepsis.
Original language | English |
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Title of host publication | Traumatic and Ischemic Injury |
Subtitle of host publication | Methods and Protocols |
Editors | Binu Tharakan |
Publisher | Humana Press |
Chapter | 16 |
Pages | 207-218 |
Number of pages | 12 |
ISBN (Electronic) | 9781493975266 |
ISBN (Print) | 9781493975242 |
DOIs | |
Publication status | Published - 22 Feb 2018 |
Publication series
Name | Methods in Molecular Biology |
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Volume | 1717 |
ISSN (Print) | 1064-3745 |
Keywords
- Acute kidney injury
- Cardiac output
- Hypotension
- Hypoxia
- Ischemia
- Renal blood flow
- Sepsis
Projects
- 1 Finished
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The pathophysiology of septic acute kidney injury
May, C., Evans, R. & Pearson, J.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/13 → 31/12/15
Project: Research