An Overview of the Bioactivities of Gedunin

Yong Sze Ong, Kooi Yeong Khaw, Loh Teng Hern Tan, Peng Nian Yew, Kai Boon Tan, Wei Hsum Yap, Siah Ying Tang, Liang Ee Low, Learn Han Lee, Bey Hing Goh

    Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

    Abstract

    Gedunin is a naturally occurring pentacyclic triterpenoid secondary metabolite presents in Meliaceae family. Since the first isolation and characterization of this compound at 1960s, the chemical synthesis and bioactive properties of this compound have been continuing researched. The plant has been historically used as the folk medicine to treat malaria and infectious diseases. Evidence-based pharmacology study showed that gedunin and its derivatives exerted enormous potential in the treatment of cancer, neurodegenerative and infectious diseases. Considering this year marks 60 years since the isolation of gedunin, this review presents an update of the bioactivity of gedunin and its derivatives with future prospect of this bioactive compound.

    Original languageEnglish
    Title of host publicationBioactive Natural Products for Pharmaceutical Applications
    EditorsDilipkumar Pal, Amit Kumar Nayak
    Place of PublicationCham Switzerland
    PublisherSpringer
    Chapter16
    Pages563-586
    Number of pages24
    ISBN (Electronic)9783030540272
    ISBN (Print)9783030540265
    DOIs
    Publication statusPublished - 2021

    Publication series

    NameAdvanced Structured Materials
    Volume140
    ISSN (Print)1869-8433
    ISSN (Electronic)1869-8441

    Keywords

    • Anti-cancer
    • Bioactivities
    • Gedunin
    • Pharmacology
    • Triterpenoid

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