An overview of epigenetic mechanisms in health and disease

Claire Westerland, Tomas Karagiannis

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Epigenetic modifications are emerging as key players in not only the regulation of normal genomic expression patterns, but also their role in disease progression due to their deregulation. An irregular change in DNA methylation, either through aberrant hypermethylation or hypomethylation, may have serious consequences relating to carcinogenesis by potentiating or preventing gene functions. Conversely, the reversal of abnormal hypermethylation has been aided by the advent of DNMT inhibitors to restore tumour suppressor gene function. In addition, the field of histone post-translational modifications (PTMs) is expanding. The best characterised and seemingly most involved in pathogenesis remain acetylation and methylation of amino acid residues within N-terminal tails. As the complexity of the epigenetic language becomes more apparent, it has been found that there is significant crosstalk between modifications, including DNA methylation and histone PTMs. Great promise lies in the development of histone deacetylase inhibiting compounds, which initiate a vast number of effects normalising or eradicating tumour cells.

Original languageEnglish
Title of host publicationMolecular Mechanisms and Physiology of Disease
Subtitle of host publicationImplications for Epigenetics and Health
EditorsNilanjana Maulik, Tom Karagiannis
PublisherSpringer
Pages81-112
Number of pages32
ISBN (Electronic)9781493907069
ISBN (Print)1493907050, 9781493907052
DOIs
Publication statusPublished - 1 Feb 2014
Externally publishedYes

Keywords

  • Acetylation
  • Chromatin remodelling
  • DNA regulation
  • Epigenetic modifications
  • Histone deacetylase inhibitors
  • Histone deacetylases
  • Methylation

Cite this

Westerland, C., & Karagiannis, T. (2014). An overview of epigenetic mechanisms in health and disease. In N. Maulik, & T. Karagiannis (Eds.), Molecular Mechanisms and Physiology of Disease: Implications for Epigenetics and Health (pp. 81-112). Springer. https://doi.org/10.1007/978-1-4939-0706-9_3
Westerland, Claire ; Karagiannis, Tomas. / An overview of epigenetic mechanisms in health and disease. Molecular Mechanisms and Physiology of Disease: Implications for Epigenetics and Health. editor / Nilanjana Maulik ; Tom Karagiannis. Springer, 2014. pp. 81-112
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Westerland, C & Karagiannis, T 2014, An overview of epigenetic mechanisms in health and disease. in N Maulik & T Karagiannis (eds), Molecular Mechanisms and Physiology of Disease: Implications for Epigenetics and Health. Springer, pp. 81-112. https://doi.org/10.1007/978-1-4939-0706-9_3

An overview of epigenetic mechanisms in health and disease. / Westerland, Claire; Karagiannis, Tomas.

Molecular Mechanisms and Physiology of Disease: Implications for Epigenetics and Health. ed. / Nilanjana Maulik; Tom Karagiannis. Springer, 2014. p. 81-112.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

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Westerland C, Karagiannis T. An overview of epigenetic mechanisms in health and disease. In Maulik N, Karagiannis T, editors, Molecular Mechanisms and Physiology of Disease: Implications for Epigenetics and Health. Springer. 2014. p. 81-112 https://doi.org/10.1007/978-1-4939-0706-9_3