An official American thoracic society workshop report: Obesity and metabolism an emerging frontier in lung health and disease

Benjamin T. Suratt, Niki D.J. Ubags, Deepa Rastogi, Kelan G. Tantisira, Benjamin J. Marsland, Irina Petrache, Janice B. Allen, Jason H T Bates, Fernando Holguin, Meredith C. McCormack, Evangelos D. Michelakis, Stephen M. Black, Manu Jain, Ana L. Mora, Viswanathan Natarajan, Yury I Miller, Michael B. Fessler, Konstantin G. Birukov, Ross S. Summer, Stephanie A. Shore

Research output: Contribution to journalArticleOtherpeer-review

Abstract

The world is in the midst of an unprecedented epidemic of obesity. This epidemic has changed the presentation and etiology of common diseases. For example, steatohepatitis, directly attributable to obesity, is now the most common cause of cirrhosis in the United States. Type 2 diabetes is increasingly being diagnosed in children. Pulmonary researchers and clinicians are just beginning to appreciate the impact of obesity and altered metabolism on common pulmonary diseases. Obesity has recently been identified as a major risk factor for the development of asthma and for acute respiratory distress syndrome. Obesity is associated with profound changes in pulmonary physiology, the development of pulmonary hypertension, sleep-disordered breathing, and altered susceptibility to pulmonary infection. In short, obesity is leading to dramatic changes in lung health and disease. Simultaneously, the rapidly developing field of metabolism, including mitochondrial function, is shifting the paradigms by which the pathophysiology of many pulmonary diseases is understood. Altered metabolism can lead to profound changes in both innate and adaptive immunity, as well as the function of structural cells. To address this emerging field, a 3-day meeting on obesity, metabolism, and lung disease was convened in October 2015 to discuss recent findings, foster research initiatives, and ultimately guide clinical care. The major findings arising from this meeting are reported in this document.

LanguageEnglish
Pages1050-1059
Number of pages10
JournalAnnals of the American Thoracic Society
Volume14
Issue number6
DOIs
StatePublished - 1 Jun 2017
Externally publishedYes

Cite this

Suratt, Benjamin T. ; Ubags, Niki D.J. ; Rastogi, Deepa ; Tantisira, Kelan G. ; Marsland, Benjamin J. ; Petrache, Irina ; Allen, Janice B. ; Bates, Jason H T ; Holguin, Fernando ; McCormack, Meredith C. ; Michelakis, Evangelos D. ; Black, Stephen M. ; Jain, Manu ; Mora, Ana L. ; Natarajan, Viswanathan ; Miller, Yury I ; Fessler, Michael B. ; Birukov, Konstantin G. ; Summer, Ross S. ; Shore, Stephanie A./ An official American thoracic society workshop report : Obesity and metabolism an emerging frontier in lung health and disease. In: Annals of the American Thoracic Society. 2017 ; Vol. 14, No. 6. pp. 1050-1059
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abstract = "The world is in the midst of an unprecedented epidemic of obesity. This epidemic has changed the presentation and etiology of common diseases. For example, steatohepatitis, directly attributable to obesity, is now the most common cause of cirrhosis in the United States. Type 2 diabetes is increasingly being diagnosed in children. Pulmonary researchers and clinicians are just beginning to appreciate the impact of obesity and altered metabolism on common pulmonary diseases. Obesity has recently been identified as a major risk factor for the development of asthma and for acute respiratory distress syndrome. Obesity is associated with profound changes in pulmonary physiology, the development of pulmonary hypertension, sleep-disordered breathing, and altered susceptibility to pulmonary infection. In short, obesity is leading to dramatic changes in lung health and disease. Simultaneously, the rapidly developing field of metabolism, including mitochondrial function, is shifting the paradigms by which the pathophysiology of many pulmonary diseases is understood. Altered metabolism can lead to profound changes in both innate and adaptive immunity, as well as the function of structural cells. To address this emerging field, a 3-day meeting on obesity, metabolism, and lung disease was convened in October 2015 to discuss recent findings, foster research initiatives, and ultimately guide clinical care. The major findings arising from this meeting are reported in this document.",
author = "Suratt, {Benjamin T.} and Ubags, {Niki D.J.} and Deepa Rastogi and Tantisira, {Kelan G.} and Marsland, {Benjamin J.} and Irina Petrache and Allen, {Janice B.} and Bates, {Jason H T} and Fernando Holguin and McCormack, {Meredith C.} and Michelakis, {Evangelos D.} and Black, {Stephen M.} and Manu Jain and Mora, {Ana L.} and Viswanathan Natarajan and Miller, {Yury I} and Fessler, {Michael B.} and Birukov, {Konstantin G.} and Summer, {Ross S.} and Shore, {Stephanie A.}",
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Suratt, BT, Ubags, NDJ, Rastogi, D, Tantisira, KG, Marsland, BJ, Petrache, I, Allen, JB, Bates, JHT, Holguin, F, McCormack, MC, Michelakis, ED, Black, SM, Jain, M, Mora, AL, Natarajan, V, Miller, YI, Fessler, MB, Birukov, KG, Summer, RS & Shore, SA 2017, 'An official American thoracic society workshop report: Obesity and metabolism an emerging frontier in lung health and disease' Annals of the American Thoracic Society, vol. 14, no. 6, pp. 1050-1059. DOI: 10.1513/AnnalsATS.201703-263WS

An official American thoracic society workshop report : Obesity and metabolism an emerging frontier in lung health and disease. / Suratt, Benjamin T.; Ubags, Niki D.J.; Rastogi, Deepa; Tantisira, Kelan G.; Marsland, Benjamin J.; Petrache, Irina; Allen, Janice B.; Bates, Jason H T; Holguin, Fernando; McCormack, Meredith C.; Michelakis, Evangelos D.; Black, Stephen M.; Jain, Manu; Mora, Ana L.; Natarajan, Viswanathan; Miller, Yury I; Fessler, Michael B.; Birukov, Konstantin G.; Summer, Ross S.; Shore, Stephanie A.

In: Annals of the American Thoracic Society, Vol. 14, No. 6, 01.06.2017, p. 1050-1059.

Research output: Contribution to journalArticleOtherpeer-review

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