Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1 - 11 |
| Number of pages | 11 |
| Journal | PLoS ONE |
| Volume | 8 |
| Issue number | 10 (Art. ID: e74123) |
| DOIs | |
| Publication status | Published - 2013 |
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An investigation on platelet transport during thrombus formation at micro-scale stenosis. / Tovar-Lopez, Francisco J; Rosengarten, Gary; Nasabi, Mahyar; Sivan, Vijay; Khoshmanesh, Khashayar; Jackson, Shaun; Mitchell, Arnan; Nesbitt, Warwick Scott.
In: PLoS ONE, Vol. 8, No. 10 (Art. ID: e74123), 2013, p. 1 - 11.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - An investigation on platelet transport during thrombus formation at micro-scale stenosis
AU - Tovar-Lopez, Francisco J
AU - Rosengarten, Gary
AU - Nasabi, Mahyar
AU - Sivan, Vijay
AU - Khoshmanesh, Khashayar
AU - Jackson, Shaun
AU - Mitchell, Arnan
AU - Nesbitt, Warwick Scott
PY - 2013
Y1 - 2013
N2 - This paper reports on an investigation of mass transport of blood cells at micro-scale stenosis where local strain-rate micro-gradients trigger platelet aggregation. Using a microfluidic flow focusing platform we investigate the blood flow streams that principally contribute to platelet aggregation under shear micro-gradient conditions. We demonstrate that relatively thin surface streams located at the channel wall are the primary contributor of platelets to the developing aggregate under shear gradient conditions. Furthermore we delineate a role for red blood cell hydrodynamic lift forces in driving enhanced advection of platelets to the stenosis wall and surface of developing aggregates. We show that this novel microfluidic platform can be effectively used to study the role of mass transport phenomena driving platelet recruitment and aggregate formation and believe that this approach will lead to a greater understanding of the mechanisms underlying shear-gradient dependent discoid platelet aggregation in the context of cardiovascular diseases such as acute coronary syndromes and ischemic stroke
AB - This paper reports on an investigation of mass transport of blood cells at micro-scale stenosis where local strain-rate micro-gradients trigger platelet aggregation. Using a microfluidic flow focusing platform we investigate the blood flow streams that principally contribute to platelet aggregation under shear micro-gradient conditions. We demonstrate that relatively thin surface streams located at the channel wall are the primary contributor of platelets to the developing aggregate under shear gradient conditions. Furthermore we delineate a role for red blood cell hydrodynamic lift forces in driving enhanced advection of platelets to the stenosis wall and surface of developing aggregates. We show that this novel microfluidic platform can be effectively used to study the role of mass transport phenomena driving platelet recruitment and aggregate formation and believe that this approach will lead to a greater understanding of the mechanisms underlying shear-gradient dependent discoid platelet aggregation in the context of cardiovascular diseases such as acute coronary syndromes and ischemic stroke
UR - http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0074123&representation=PDF
U2 - 10.1371/journal.pone.0074123
DO - 10.1371/journal.pone.0074123
M3 - Article
VL - 8
SP - 1
EP - 11
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 10 (Art. ID: e74123)
ER -