An investigation of white matter integrity and attention deficits following traumatic brain injury

Jacqueline Anne Owens, Gershon Spitz, Jennie Louise Ponsford, Alicia Rhian Dymowski, Catherine Willmott

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective: This study aimed to investigate the association between white matter tracts and multiple aspects of attention and working memory deficits in a relatively acute traumatic brain injury (TBI) sample. Method: Neuropsychological measures of attention and working memory were administered to 20 participants with complicated mild-to-very severe TBI and 20 control participants. Tract-based spatial statistics was used to assess fractional anisotropy (FA) and mean diffusivity (MD) of white matter tracts for 15 TBI participants and 20 controls. Results: When compared to controls, participants with TBI were found to have lower FA (p < 0.001) and higher MD (p < 0.001) values in the majority of white matter tracts. TBI participants were also slower to complete tasks including Trail Making Test, Hayling, computerized Selective Attention Task, n-back and Symbol Digit Modalities Test (p < 0.001), when compared to controls. When controlling for age and estimated premorbid intelligence, slowed information processing speed following TBI was found to be associated with FA values in the corpus callosum, superior longitudinal fasciculus, cingulum, inferior fronto-occipital fasciculi, corona radiata and cerebral white matter. Conclusion: The results highlight the widespread damage associated with TBI, as well as the impact of these alterations on information processing speed.

Original languageEnglish
Pages (from-to)776-783
Number of pages8
JournalBrain Injury
Volume32
Issue number6
DOIs
Publication statusPublished - 22 Mar 2018

Keywords

  • attention
  • diffusion tensor imaging
  • processing speed
  • tract-based spatial statistics
  • Traumatic brain injury

Cite this

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abstract = "Objective: This study aimed to investigate the association between white matter tracts and multiple aspects of attention and working memory deficits in a relatively acute traumatic brain injury (TBI) sample. Method: Neuropsychological measures of attention and working memory were administered to 20 participants with complicated mild-to-very severe TBI and 20 control participants. Tract-based spatial statistics was used to assess fractional anisotropy (FA) and mean diffusivity (MD) of white matter tracts for 15 TBI participants and 20 controls. Results: When compared to controls, participants with TBI were found to have lower FA (p < 0.001) and higher MD (p < 0.001) values in the majority of white matter tracts. TBI participants were also slower to complete tasks including Trail Making Test, Hayling, computerized Selective Attention Task, n-back and Symbol Digit Modalities Test (p < 0.001), when compared to controls. When controlling for age and estimated premorbid intelligence, slowed information processing speed following TBI was found to be associated with FA values in the corpus callosum, superior longitudinal fasciculus, cingulum, inferior fronto-occipital fasciculi, corona radiata and cerebral white matter. Conclusion: The results highlight the widespread damage associated with TBI, as well as the impact of these alterations on information processing speed.",
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An investigation of white matter integrity and attention deficits following traumatic brain injury. / Owens, Jacqueline Anne; Spitz, Gershon; Ponsford, Jennie Louise; Dymowski, Alicia Rhian; Willmott, Catherine.

In: Brain Injury, Vol. 32, No. 6, 22.03.2018, p. 776-783.

Research output: Contribution to journalArticleResearchpeer-review

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