An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells

Woo-Yong Lee, Tara Moriarty, Connie Hoi Yee Wong, Hong Zhou, Robert M Strieter, Nico van Rooijen, George Chaconas, Paul Kubes

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223 Citations (Scopus)

Abstract

Here we investigate the dynamics of the hepatic intravascular immune response to a pathogen relevant to invariant natural killer T cells (iNKT cells). Immobilized Kupffer cells with highly ramified extended processes into multiple sinusoids could effectively capture blood-borne, disseminating Borrelia burgdorferi, creating a highly efficient surveillance and filtering system. After ingesting B. burgdorferi, Kupffer cells induced chemokine receptor CXCR3-dependent clustering of iNKT cells. Kupffer cells and iNKT cells formed stable contacts via the antigen-presenting molecule CD1d, which led to iNKT cell activation. An absence of iNKT cells caused B. burgdorferi to leave the blood and enter the joints more effectively. B. burgdorferi that escaped Kupffer cells entered the liver parenchyma and survived despite Ito cell responses. Kupffer cell-iNKT cell interactions induced a key intravascular immune response that diminished the dissemination of B. burgdorferi.
Original languageEnglish
Pages (from-to)295 - 302
Number of pages8
JournalNature Immunology
Volume11
Issue number4
DOIs
Publication statusPublished - 2010
Externally publishedYes

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